The knowledge that melanoma is susceptible to attack by the host’s immune Abstract system has resulted in the testing of a variety of immunotherapies. Interferon-α-2b, which has several anti-tumour mechanisms including an antiproliferative effect, an anti-angiogenesis effect, the enhancement of natural-killer cell activity and the upregulation of tumour antigen presentation, has shown tremendou...

background: high level radiation areas have been recognized on various parts of the earth. mahallat hot spring region is one of these areas. study of exposure in these areas can be helpful in investigating the effects of ionizing radiation. internal and external exposure to the staff was studied. materials and methods: used materials and instruments include: rss-112 ionizing chamber for environ...

introduction patients with hepatitis c are commonly treated with combination of pegylated interferon alfa-2a and ribavirin. less than 1% of patients receiving this treatment experience very uncommon ophthalmological side effects such as optic neuropathy and vision disorder, which are usually subclinical, mild and reversible, not requiring the withdrawal of the treatment. retinopathy is the most...

BACKGROUND Despite advances in the staging and surgical therapy of melanoma, patients with high-risk resected melanoma still have 5-year recurrence rates of 55% to 80% and 5-year survival rates as low as 25% to 70%. Effective adjuvant therapy is needed for this patient population. METHODS The authors review the literature regarding the use of interferon for the adjuvant therapy of resected me...

Polyriboinosinic-polyribocytidylic acid, stabilized with poly L-Iysine and carboxymethylcellulose [poly(ICLC)], resists hy drolysis by primate serum (unlike the parent compound), in duces high levels of serum interferon, and is effective in acute viral infections of subhuman primates. In a Phase I clinical trial, poly(ICLC)was given i.v. in 15 daily dosesof 0.5 to 27.0 mg/ sq m to 19 patients w...