The purpose of this study was to examine the development of the ultrasonic image and histology of rabbit leg muscles irradiated with high-intensity focused ultrasound (HIFU). HIFU was applied to muscles of 40 legs of 20 rabbits. The results of sonication were examined by ultrasound from 10 min to 28 days after HIFU radiation in 19 rabbits. Pathological examination was performed on Day 1 and Day...

PURPOSE To evaluate therapeutic efficacy of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) ablation for treatment of needle-track seeding of hepatocellular carcinoma (HCC). MATERIALS AND METHODS Nine patients with needle-track seeding of HCC were treated as outpatients using US-guided HIFU ablation. The mean size of the lesion was 1.8 cm (range 1.1 to 2.6 cm), two lesions wer...

The successful clinical application of high intensity focused ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic motion imaging guided focused ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monito...

Characterization of high-intensity focused ultrasound (HIFU) systems using ex vivo tissues is an important part of the preclinical testing for new HIFU devices. In ex vivo characterization, the lesion volume produced by the absorption of HIFU energy is quantified as operational parameters are varied. This paper examines the three methods used for lesion-volume quantification: histology, magneti...

Organ motion is a key component in the treatment of abdominal tumors by High Intensity Focused Ultrasound (HIFU), since it may influence the safety, efficacy and treatment time. Here we report the development in a porcine model of an Ultrasound (US) image-based dynamic fusion modeling method for predicting the effect of in vivo motion on intraoperative HIFU treatments performed in the liver in ...

BACKGROUND High intensity focused ultrasound (HIFU) has been introduced for treatment of cardiac arrhythmias because it offers the ability to create rapid tissue modification in confined volumes without directly contacting the myocardium. In spite of the benefits of HIFU, a number of limitations have been reported, which hindered its clinical adoption. METHODS AND RESULTS In this study, we us...

Passive cavitation images (PCIs) generated from scattered acoustic waves are a potential technique for monitoring lesion formation during high-intensity focused ultrasound (HIFU) thermal ablation. HIFU lesion prediction by PCIs was assessed in ex vivo bovine liver samples (N=14) during 30-s sonications with 1.1-MHz continuous-wave ultrasound (1989 W/cm^2 estimated spatial-peak intensity). Treat...

Understanding the effect of overlaying tissues on HIFU lesion is crucial for estimating HIFU dose distribution at a target tissue. We have run a series of experiments to systematically observe the effects of the overlaying tissues on the HIFU beam and ultimately the lesion created in the target tissue. First, we mapped out the HIFU transducer beam (in low power) under water without and with dif...

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU mo...

Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of High-Intensity Focused Ultrasound (HIFU) surgery. However, accurate localization and characterization of the effective region of treatment (thermal lesion) remain the obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a novel HIFU ...