background: we aimed to reveal the role of cd11b and hypoxia-inducible factors-1alpha (hif-1α) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-d (sp-d) in severe malaria-associated acute lung injury (ali). methods: the c57bl/6 mice were divided into control group, renal malaria group (inoculated with 10 6 plasmodium berghei anka), and...

Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...

Abstract Study question Does HIF-2α play a key role in pre-menstrual conditioning of the non-pregnant endometrium to optimise menstrual breakdown/repair and prevent heavy bleeding (HMB)? Summary answer HIF-2 was higher secretory women with HMB versus controls, but manipulation mouse model did not impact endometrial breakdown/repair. What is known already Hypoxia inducible factor (HIF) master re...

One of the most fundamental molecular processes in response to hypoxia is activation and stabilization a transcriptional factor called induced 1a (HIF-1a), which responsible for regulation many downstream effector genes. Multiple key biological pathways such as proliferation, energy metabolism, invasion, metastasis are governed by these This article discusses role hypoxia-inducible (HIF-1a) met...

Aim Hypoxia-inducible factors (HIFs) are O2-sensitive transcription that regulate multiple biological processes which essential for cellular adaptation to hypoxia. Small molecule inhibitors of HIF-prolyl hydroxylase domain (PHD) dioxygenases (HIF-PHIs) activate HIF-dependent transcriptional programs and have broad clinical potential. HIF-PHIs currently in global late-stage development the treat...

Objective(s): Previous study has indicated that triiodothyronine (T3) facilitated cartilage degeneration in osteoarthritis (OA). This study aimed to investigate the effects of T3 on angiogenesis-related factor expression in human osteoblasts of OA subchondral bone.Materials and Methods: The subchondral bone specimens were obtained from O...

Recent studies have provided novel insights of co-development the neural and vascular elements retina. Knowledge these relationships are crucial to understand impact therapeutic measures in Retinopathy Prematurity (ROP). ROP is imposed by oxygen upon immature retinal blood vessels cells causing delayed development regression. However, hyperoxia on developing neurons less understood because some...