(Received for publication, November 12, 1956) In view of the blocking effect of hexamethonium on the autonomic ganglia it is deemed desirable to ascertain whether the adrenal medulla is also paralysed by hexamethonium. The previously reported work1) provided evidence that the accelera tion of adrenaline secretion causable by acetylcholine was definitely suppressed by hexamethonium. Following up...

The present study investigated the effects of microinjections of acetylcholine (a cholinergic agonist), physostigmine (a cholinesterase inhibitor), atropine (an antagonist of muscarinic cholinergic receptors) and hexamethonium (an antagonist of nicotinic cholinergic receptors) into the parafascicular nucleus of thalamus on the acute corneal nociception in rats. Acute corneal nociception was ind...

Hypotensive doses of hexamethonium were administered intravenously to 19 patients with various types of heart disease in congestive failure. Clinical improvement as judged by the usual methods was seen in most cases. Intracardiac or pulmonary artery pressures paralleled the fall of arterial pressures following hexamethonium in four patients with hypertensive heart disease in congestive failure....

We recently identified hexamethonium-resistant peristalsis in the guinea pig colon. We showed that, following acute blockade of nicotinic receptors, peristalsis recovers, leading to normal propagation velocities of fecal pellets along the colon. This raises the fundamental question: what mechanisms underlie hexamethonium-resistant peristalsis? We investigated whether blockade of the major recep...

Reports of rapid accumulation of 3Hor 14C-labelled hexamethonium in cartilaginous tissues after intravenous administration to rats and mice and of binding of hexamethonium to chondroitin sulfate in uitro prompted synthesis of radioiodinated analogs of hexamethonium. Tissue distribution studies in rats performed at 0.5 and 2 h after intravenous administration of “C-hexamethonium confirmed the pr...