Aberrant activation of Wnt/ -catenin signaling and subsequent up-regulation of -catenin response transcription (CRT) is a critical event in the development of human colon cancer. Thus, Wnt/ -catenin signaling is an attractive target for the development of anticancer therapeutics. In this study, we identified hexachlorophene as an inhibitor of Wnt/ -catenin signaling from cell-based small-molecu...

HEXACHLOROPHENE AND SKIN CARE OF NEWBORN INFANTS T HE question of safety has been raised by the recent evidence that levels of hexachlorophene in the blood of newborn infants receiving daily baths with a 3% solution are close to levels which are neurotoxic for adult rats.’ Hexachlorophene is widely used in newborn nurseries, but techniques vary considerably; they range from meticulous, double, ...

Sir,-We read with concem the correspondence from Hardell (1992; 49:743) who speculates on a causal relation between exposure to dioxin in hexachlorophene and the development of soft tissue sarcoma in a patient 17 years later. The author seems to be unaware of several considerations that would be relevant to the scientific establishment of a cause and effect relation in this case. Firstly, dioxi...

Type II fatty acid biosynthesis represents an attractive target for the discovery of new antimalarial drugs. Previous studies have identified malarial ENR (enoyl acyl-carrier-protein reductase, or FabI) as the target for the antiseptic triclosan. In the present paper, we report the biochemical properties and 1.5 A (1 A=0.1 nm) crystal structure of OAR (3-oxoacyl acyl-carrier-protein reductase, ...

Thioglycollate Broth Medium was used for culturing the test bacteria. Thioglycollate Broth Medium containing 0.5% sodium thiosulfate, O.S^o Tween ® 80, and 0.07% lecithin was used as the transplant medium. The sodium thiosulfate inactivates free iodine which mav be carried over. The Tween ® 80 and lecithin serve as inactivators for the quaternary compounds and hexachlorophene, and thioglycollat...

recent research highlights the importance of gsts in the establishment of chronic helminth infections. gsts have the potential to protect the parasite against the host immune response. in this present study, gst enzyme assay has been investigated on whole extract of f. hepatica and sheep liver tissue. to the 1-ml plastic cuvette, added 200 mm potassium phosphate buffer. then added 50 mm gsh red...