نتایج جستجو برای: hesi
تعداد نتایج: 107 فیلتر نتایج به سال:
The Note for Guidance ICH S1B Testing for Carcinogenicity of Pharmaceuticals (CPMP/ICH/299/95) offers the option to use short or medium-term in vivo rodent test systems, such as transgenic and knockout animal models, in place of a second 2-year rodent bioassay. Ideally, such studies should supplement the long-term carcinogenicity study and provide additional information that is not readily avai...
The ILSI Health and Environmental Sciences Institute (HESI) hosted an expert workshop 22-24 February 2005 in Mallorca, Spain, to review the state-of-the-science for conducting a sequence homology/bioinformatics evaluation in the context of a comprehensive allergenicity assessment for novel proteins, to obtain consensus on the value and role of bioinformatics in evaluating novel proteins, and to...
The European Union's Registration, Evaluation and Authorisation of Chemicals (REACH) legislation mandates testing and evaluation of approximately 30,000 existing substances within a short period of time, beginning with the most widely used "high production volume" (HPV) chemicals. REACH testing requirements for the roughly 3000 HPV chemicals specify three separate tests for reproductive toxicit...
Abbreviations: UHPLC: Ultra-High-Performance Liquid Chromatography; HESI: Heated Electrospray Ionization; MS: Mass Spectrometry; MS/ MS: Tandem Mass Spectrometry; BCS: Biopharmaceutics Classification System; FDA: Food and Drug Administration; PK: Pharmacokinetic; IS: Internal Standard; m/z: mass-to-charge ratio; Cmax: Peak Plasma Concentration of Drug; Tmax: Time required to reach the peak plas...
The Southern Levant is a pivotal area for the study of hominin paleoecology during the Lower Paleolithic, because of its location on the out-of-Africa dispersal route and its significant ecological diversity. Important information has been gained by archaeofaunal studies, which usually reveal that exploitation of diverse Mediterranean environments with woodlands, marshes and lake margins, repre...
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several genetically modified mouse assays for assessing the human carcinogenic potential of compounds. The data from this testing program have made an importa...
Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from nonclinical to clinical data. Fluid-based biomarkers such as those found in ...
The ILSI/HESI Workshop on Alternatives to Carcinogenicity Testing aims to develop and apply new methods for assessment of potential carcinogenic risk to humans from various chemicals. The Workshop represents a major cooperative scientific effort. The long-term goals should be to greatly enhance the efficiency and reliability of such testing and to supplant, not just supplement, lifetime rodent ...
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