Background: Kerack is emerging illicit substance which its use is rising up in Iran. It has harmful effects on body organs. The aim of this study is to investigate the effects of Iranian Kerack on sperm parameters and testicular structure of mice. Materials and Methods: In this study, 25 male mice (Balb/C) were divided into five groups (control, sham and three experimental). Experimental groups...

Iranian crack is a new form of narcotic substance that has found widespread prevalence inIran in the past years. crack only nominally resembles crack cocaine as it is widely different inits clinical signs. Thus the present study aims to quantify the chemical combination of this drug.The samples included 18 specimen of crack collected from different zones of Tehran, Iran.All specimens were in th...

background: opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  heroin is one of the opioid derivatives that abuse increasingly today.  so far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion.   objective:  to define the effect of the acute heroin consumption on basal and vagal-sti...

Iranian crack is a new form of narcotic substance that has found widespread prevalence inIran in the past years. crack only nominally resembles crack cocaine as it is widely different inits clinical signs. Thus the present study aims to quantify the chemical combination of this drug.The samples included 18 specimen of crack collected from different zones of Tehran, Iran.All specimens were in th...

The purpose of this study was to evaluate the effects of a morphine-conjugate vaccine (M-KLH) on the acquisition, maintenance, and reinstatement of heroin self-administration (HSA) in rats, and on heroin and metabolite distribution during heroin administration that approximated the self-administered dosing rate. Vaccination with M-KLH blocked heroin-primed reinstatement of heroin responding. Va...

background : magnetic resonance imaging (mri) offers higher diagnostic accuracy for brain lesions caused by heroin abuse compared to compute tomography (ct) scan. these lesions have a low signal on t1-weighted (t1w) images and a high signal on t2-weighted (t2w) and fluid-attenuated inversion recovery (flair) images. this study aimed to evaluate the role of diffusion-weighted mri (dwi-mri) in he...

Heroin abuse has been a long-standing problem in the United States, especially in New York City, which is a major heroin trafficking center and home to the largest population of heroin addicts in the country. As a consequence, New York City is also the major center for methadone treatment. Over time, however, the heroin problem seems to have changed in terms of demographic characteristics of ab...

Long-term changes in glutamate transmission in the nucleus accumbens core (NAcore) contribute to the reinstatement of drug seeking after extinction of cocaine self-administration. Whether similar adaptations in glutamate transmission occur during heroin and cue-induced reinstatement of heroin seeking is unknown. After 2 weeks of heroin self-administration and 2 weeks of subsequent extinction tr...

Abstract Background The misuse of illicit substances is associated with increased morbidity and mortality; thus, substance abuse a global health concern. Arabian Gulf region considered crossing point consumer drugs. However, lack laboratory-based research has limited the scientific assessment drug in region. Thus, an up-to-date analytical representation situation warranted. Methods We investiga...