نتایج جستجو برای: heritability
تعداد نتایج: 10805 فیلتر نتایج به سال:
We examine heritability estimation of an ordinal trait for osteoarthritis, using a population of pig-tailed macaques from the Washington National Primate Research Center (WaNPRC). This estimation is non-trivial, as the data consist of ordinal measurements on 16 intervertebral spaces throughout each macaque's spinal cord, with many missing values. We examine the resulting heritability estimates ...
BACKGROUND AND OBJECTIVE Almost 100% individuals with coeliac disease (CD) are carriers of the human leucocyte antigen (HLA) DQ2/DQ8 alleles. Earlier studies have, however, failed to consider the HLA system when estimating heritability in CD, thus violating an underlying assumption of heritability analysis. We examined the heritability of CD in a large population-based sample of twins, consider...
The discovery and prioritization of heritable phenotypes is a computational challenge in a variety of settings, including neuroimaging genetics and analyses of the vast phenotypic repositories in electronic health record systems and population-based biobanks. Classical estimates of heritability require twin or pedigree data, which can be costly and difficult to acquire. Genome-wide complex trai...
Considerable variability exists in patterns of brain aging within and across individuals. Quantifying familial contributions to brain structure in late life may help us understand this variability. We estimated heritability of gray and white matter volumes and cortical thickness in a sample of older adult full siblings (2-4 individuals per pedigree; N = 75). Estimation of heritability was based...
autoselection is a kind of natural selection, that occurs in reproductive traits by inequality of offspring generation and therefore by virtue of the nature of its genes transmission to next generations. in this study, the effects of autoselection on heritability and selection response in reproductive traits by using univariate stochastic computer simulation in artificial selected and unselecte...
the objective of the article is to investigate the variability in growth and wood properties of the willow clones. the growth and wood traits of four year old 21 clones willow clones were investigated. analysis of variance showed that willow clones differed significantly for all the studied growth and wood traits. among the growth parameters the maximum heritability value was shown by height wh...
BACKGROUND Twin and multiplex family studies have established significant heritability for schizophrenia (SZ), often summarized as 81%. The Consortium on the Genetics of Schizophrenia (COGS-1) family study was designed to deconstruct the genetic architecture of SZ using neurocognitive and neurophysiological endophenotypes, for which heritability estimates ranged from 18% to 50% (mean = 30%). Th...
For most complex traits, results from genome-wide association studies show that the proportion of the phenotypic variance attributable to the additive effects of individual SNPs, that is, the heritability explained by the SNPs, is substantially less than the estimate of heritability obtained by standard methods using correlations between relatives. This difference has been called the "missing h...
Heritability and interactions of yield and growth traits were assessed in Hevea brasiliensis using full-sib progenies and clonal populations. Using parent-offspring regression, annual mean rubber yield (ARY) and summer yield (SY) showed moderate to high heritability (ARY, h2 =34–56%; SY, h2 =36–52%). Among the yield components, girth exhibited low to moderate heritability (h2 =17–36%) while bra...
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