نتایج جستجو برای: her2neu protein
تعداد نتایج: 1234734 فیلتر نتایج به سال:
Background & Aims: Breast cancer is the most prevalent malignancy in women. A few articles describe a marked decrease in the levels of ferroportin in breast cancer cells.The presented results demonstrate convincingly the incredible diagnostic and prognostic value of ferroportin expression in breast cancer and suggest that determination of this molecular marker maybe used as guidance toward ind...
Purpose. Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neu expressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters. Materials and Methods. Thirty-six female patients w...
Bilateral breast cancer incidence is appreciated to be between 0.3 to 12% and is determined either by a hereditary load associated with chromosomal instability under the effect of environmental factors, or by the evolution in a particular hormonal context which gives biological aggressiveness. We present the case of a patient, aged 38 years, clinically, imagistic and bioptic diagnosed with left...
Background and Aims Gastric cancer is the third most common cause of cancer-related mortality worldwide after lungs colorectum. Although controversial, Her2neu overexpression by immunohistochemistry usually associated with poor prognosis in patients carcinoma stomach. We conducted a prospective study to evaluate prognostic role its correlation clinical, pathologic type, stage disease. Methods A...
Mutation or amplification in the PIK3CA gene is one of most frequent somatic mutations hormone-dependent Her2neu-negative breast cancer (HR+ Her2neu- cancer) and associated with an increased risk relapse, progression death. Understanding mechanisms leading to hyperactivation PI3K-mediated signaling cascade has led a new class drugs aimed at inhibiting/suppressing it. Studies efficacy pan-PI3K i...
Editorial Targeted therapies; who detects the target? After decades in which anti-cancer drugs mainly were designed to inhibit tumor cell proliferation or to interfere with DNA integrity in order to induce apop-tosis in a very general way, we recently have been witnessing the development of a new class of anticancer drugs specifically targeted at biological properties of tumor cells. Examples a...
Patients and methods 50 women with breast cancer and a BRCA1 mutation, who presented with stage I to III breast cancer between December 2006 and April 2010 were enrolled and treated with cisplatin 75 mg/m every three weeks for four cycles, followed by mastectomy and conventional chemotherapy. Eight patients had prior chemotherapy for a previous cancer diagnosis. Three patients received prior ch...
بررسی بیان ژنهای دخیل در سیستم دفاعی گندم نسبت به mycosphaerella graminicola با استفاده از cdna-aflp
aflp یک ابزار قدرتمند برای تشخیص رونوشت هایی با فراوانی کم است و می تواند بعنوان یک روش کارآمد برای جداسازی ژنهایی که بطور متمایز بیان می شوند، بکار رود. بنابراین القا متمایز ژنها در گندم ( رقم چمران و مرودشت) در پاسخ به قارچ m.graminicola بوسیله آنالیز cdna-aflp مورد مطالعه قرار گرفت . در ابتدا گیاهان بوسیله بیمارگر مایه زنی شدند. نمونه برداری در 6 نقطه زمانی(0، 12، 24، 48، 72 و 96 ساعت) بعد ا...
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