نتایج جستجو برای: her2 antigen
تعداد نتایج: 214094 فیلتر نتایج به سال:
Background Solid tumors display pronounced antigen heterogeneity and clinical studies have shown that escape from therapy occurs rapidly, limiting the persistence efficacy of CAR T cells. Here we present dual triple-antigen binding proteins bridge cells to multiple antigens, allowing a simultaneous attack on tumor antigens by single antibody domain. We call these Engager proteins. can be encode...
PURPOSE We developed a complex of tumor antigen protein with a novel nanoparticle antigen delivery system of cholesteryl pullulan (CHP). To target HER2 antigen, we prepared truncated HER2 protein 1-146 (146HER2) complexed with CHP, the CHP-HER2 vaccine. We designed a clinical study to assess the safety of the vaccine and HER2-specific T-cell immune responses measured by the newly developed enzy...
Background We have previously demonstrated the efficacy of HER2 specific chimeric antigen receptor (CAR) T cells in animal models of human cancer. While HER2 CAR T cells induced tumor regression, tumors recurred in a subset of animals. Lytic co-targeting of the tumor endothelium could represent a strategy that enhances tumor control. Tumor endothelium marker 8 (TEM8) is a recently described tum...
BACKGROUND HER2 is overexpressed in 20-30% of breast cancers. Compared to chemotherapy alone, chemotherapy with trastuzumab improves clinical outcome in patients with HER2-positive metastatic breast cancer (MBC). In general, HER2 status in a primary lesion predicts the status of metastases, so that biopsy of metastatic lesions appears unnecessary. CASE REPORT A 39-year old woman was diagnosed...
The identification and characterization of tumor antigens has facilitated the development of immune-based cancer prophylaxis and therapy. Cancer vaccines, like viral vaccines, may be effective in cancer prevention. Adoptive T-cell therapy, in contrast, may be more efficacious for the eradication of existing malignancies. Our group is examining the feasibility of antigen-specific adoptive T-cell...
Bispecific antibodies (BsAbs) have been developed, with one antigen-binding site coordinated against the CD3 receptor (which activates cytotoxic T lymphocytes) and other specific antigens found on cancer cells (CD19, CD20, CD33, CD123, HER2, epithelial cell adhesion molecule [EpCAM], BCMA, CEA, others) [1].
The reliability of the rabbit monoclonal antibodies SP1, SP2, SP3, and 4B5 was immunohistochemically assessed on a range of 96 invasive breast carcinomas and the results compared with those achieved with established antibody markers for estrogen receptors (6F11), progesterone receptors (PgR636), and HER2 (polyclonal A0485 and clone CB11), with HER2 status validated by fluorescence in situ hybri...
The quality of chimeric antigen receptor (CAR)-T cell products, including the expression memory and exhaustion markers, has been shown to influence their long-term functionality. manufacturing process CAR-T cells should be optimized prevent early T during expansion. Activation by monoclonal antibodies is a critical step for expansion, which may sometimes induce excess stimulation cells. Given t...
Immunization of metastatic breast cancer patients with CD80-modified breast cancer cells and GM-CSF.
Tumor-assocla,ted antigens have been identified on a variety of human neoplasms. Each of these antigens may be able to serve as a target for an immune respOf.lse, the result of which would be eliminatjon of the tumor celL An essential component of this immune response is the presentation of antigen to potential effector cells. This can be accom plished via host professional antigen~presenting ...
BACKGROUND Anti-CD11c antibodies target to the CD11c receptor that mediates antigen presentation to T cells by dendritic cells (DCs). To exploit these properties for immunization purposes, we obtained DC-targeting DNA vaccines by fusing tumor-associated antigen HER2/neu ectodomain to single chain antibody fragment (scFv) from N418 (scFv(N418)), a monoclonal antibody binding the mouse DC-restric...
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