The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

introduction : fibrolamellar carcinoma (flc), a subtype of hepatocellular carcinoma (hcc), is a rare primary hepatic malignancy. several aspects of the clinical features and epidemiology of flc remain unclear since most literature on flc consists of case reports and small cases series with limited information on factors that affect survival. majority of the tumors occurred in patients less than...

Objective(s): Although low-dose radiotherapy (RT) that involves low collateral damage is more suitable for hepatocellular carcinoma (HCC) than traditional high-dose RT, but to achieve satisfactory therapeutic effect with low-dose RT, it is necessary to sensitize HCC cells to irradiation. This study was aimed to determine whether radiosensitivity of HCC cells can be enhanced using miR-26b by tar...

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

background: hepatocellular carcinoma (hcc) is a primary liver cancer that frequently causes mortalities. transarterial chemoembolization (tace) is a new palliative treatment for advanced stages of hcc. in this study, we have assessed the results of tace on a group of iranian patients with advanced hcc treated at imam khomeini general hospital. materials and methods: this was a case series, coho...

Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in hepatocellular carcinoma cells (HCC). However, the function of miR-92a is still unclear in HCC. Materials and Methods: Expression of miR-92a in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of miR-92a in HepG2 and ...

Hepatocellular carcinoma (HCC) is the most common cancer of digestive system. Recently, transmembrane proteins (TMEMs) have been extensively studied in different types malignant tumors. However, influence TMEM206 hepatocellular unclear. The UALCAN database was used to investigate expression mRNA liver tissues and Human Protein Atlas (THPA) study HCC tissues. measured normal HL-7702 cells HepG2,...

Discrimination of regenerative cirrhotic nodules of the liver (CN) from hepatocellular carcinoma (HCC) is sometimes difficult. We examined the utility of AgNOR staining in this context. Fifteen cases of HCC and 25 cases of CN were stained by AgNOR method and the mean AgNOR number for one hundred nuclei in each case was determined. There was a significant difference between the mean AgNOR c...

Hepatocellular carcinoma (HCC) is considered a classic inflammation-associated tumor that usually originates from chronic hepatitis, where an intense and inflammatory response leads to the accumulation of mutations eventually carcinogenesis under conditions persistent liver injury. In recent years, immunotherapy for HCC has continued evolve, as naturally filled with large variety immune cells, ...

background: the association between hepatitis b virus (hbv) mutations and hepatocarcinogenesis were reported in the literature. preference for g over c in the leading dna strand has been reported to account for the asymmetry in nucleotide (nt) composition. the aim of this study was to analyze the complete genome sequence and compositional asymmetry of hbv in different stages of hepatitis b. met...