background: telomerase activity increases in cancer cells. bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including hepatocellular carcinoma cells. in this study, an attempt was made to investigate the effects of a new synthetic compound, platinum azidothymidine (pt-azt) on treatment of rats with hepatocellular carcinoma (hcc) and to compare its effects with ...

context primary liver cancer is one of the most common and deadly malignant neoplasms worldwide. the incidence and mortality rates for hepatocellular carcinoma (hcc) are virtually identical, reflecting the poor overall survival of patients with this kind of tumor. effective therapies mostly achieved if the hcc diagnosis is made at early stages of the tumor. surveillance tests include serologic ...

contexts hepatocellular carcinoma (hcc) is one of the most common malignant diseases in the world. because less than 20% of patients with hcc are resectable, various types of non-surgical treatment have been developed. evidence acquisition at present, radiofrequency ablation (rfa) is accepted as the standard local treatment for patients with hcc because of its superior local control and overall...

conclusions plasma opn is comparable to afp as a diagnostic marker and is related to the severity of liver involvement in hcc patients. plasma opn is of diagnostic potential value in nafld. background osteopontin (opn) is a secreted glycoprotein and is frequently associated with various tumors. objectives we sought to investigate the clinical usefulness of the level of plasma opn, compared to α...

hepatocellular carcinoma (hcc) is the most common, malignant tumor of the liver. hepatocellular carcinoma (hcc) commonly metastasizes to the lungs, abdominal lymph nodes, adrenal glands, or bones. distant lymph node metastases are rare in hepatocellular carcinoma. a 49-year-old male patient presented with right sided neck mass. on examination there was right cervical lymphadenopathy and hepatom...

materials and methods the expression of gp73 was investigated in 88 cancerous and self-control non-cancerous tissues using tissue microarrays with immunohisto- chemistry and was confirmed by western blotting. circulating gp73 levels were detected in the sera of 281 patients with liver diseases using enzyme-linked immunosorbent assay. results the levels of circulating gp73 expression in the hcc ...

hepatocellular carcinoma (hcc) is very rare during pregnancy and has a worse prognosis in pregnant women compared to those who are not pregnant. we present a case of hcc in a 41- year-old pregnant patient who was referred to our academic hospital. the patient presented with chief complaints of abdominal pain, jaundice, edema and hypertension. laboratory results were notable for elevated liver e...

Background: One of the most important causes of chronic liver disease is hepatitis C virus (HCV), which causes liver cirrhosis and hepatocellular carcinoma. To control the prevalence of the disease, knowledge and information in risk factor of HCV are required. The aim of this study was to compare the risk factors of infection between HCV patients with genotypes 1a and 3a. Methods: This is an o...

[Original]Hepatocellular carcinoma (HCC) is the most common primary neoplasm of liver, which arises from parenchymal cells liver.1 Hepatocellular usually develops in setting chronic background liver disease, such as cirrhosis or hepatitis B C infection. The diagnosis HCC relies heavily on diagnostic imaging, and high sensitivity specificity Liver Imaging Reporting Data System (LI-RADS) classifi...

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...