A marginally lipotrope-deficient diet, high in fat, enhances hepatocarcinogenesis by aflatoxin B, , diethyland dibutyl-ni trosamine, or N-2-fluorenylacetamide and colon carcinogene sis by 1,2-dimethylhydrazine in rats, when compared to a nutritionally complete diet that differs in several components from the deficient diet. Supplementation of the deficient diet with lipotropes and amino acids d...

BACKGROUND Diverse environmental contaminants, including the plasticizer di(2-ethylhexyl)phthalate (DEHP), are hepatocarcinogenic peroxisome proliferators in rodents. Peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation and its sequelae have been proposed to constitute a mode of action (MOA) for hepatocarcinogenesis by such agents as a sole causative factor. Further, based o...

Hepatocellular carcinoma is usually preceded by chronic inflammation. However, the molecular mechanism in hepatocarcinogenesis is not well known. Recently, we reported that mitochondrial dysfunction plays an important role in hepatocarcinogenesis via the production of free radicals. Furthermore, we proved that L-carnitine effectively protects mitochondrial function in vivo. Therefore, we invest...

Little is known about the involvement of Smad-related molecules in the regulation of the Transforming Growth Factor (TGF)-beta signaling pathway during hepatocarcinogenesis, particularly with respect to preneoplastic lesions of a rat liver. The aims of this study were to investigate the localizations and temporal expressions of TGF-beta Receptor Type 1 (TGR1) and Smads during the promotion stag...

Understanding the important alterations during hepatocarcinogenesis as well as the characteristic magnetic resonance imaging (MRI) and histopathological features will be helpful for managing patients with chronic liver disease and hepatocellular carcinoma. Recent advances in MRI techniques, such as fat/iron quantification, diffusion-weighted images, and gadoxetic acid-enhanced MRI, have greatly...

abstract objective : in this study, we have undertaken efforts to ascertain the anticancer potency of s. crispus (sc) extract on diethylnitrosamine (den) and acetylaminofluorene (aaf) induced hcc with special attention to hepatic drug metabolism and to investigate the effect of sc on preneoplastic marker enzyme activity specifically of microsomal aniline hydroxylase (ah) activity and lesion sco...

abstract objective: cancer is the second cause of death worldwide, among them liver cancer is the fifth most important malignancy. the aim of this study was to investigate chemopreventive activity of berberis vulgaris fruit extract in  hepatocarcinogenesis  sprague dawley rats. materials and methods: fourty-four sprague dawley rats (6-8 weeks old, 150-250g) were divided into normal and cancerou...