Benzene is a volatile chemical implicated in leukemia and hepatic injury through oxidative stress-mediated mechanism. Linalool naturally small molecular monoterpene with proven antioxidant pro...

Background: Acetaminophen overdose can result in hepatic injury, mainly through oxidative stress. Objective: We investigated the protective effect of Cuminum cyminum (C. cyminum) seed powder after acetaminophen administration. Methods: Thirty male rats were divided into five groups (n=6): Control group, Acetaminophen (A) group, and Acetaminophen + C. cyminum 200, 400, 800 mg/kg (A+C) groups. Af...

OBJECTIVE To investigate the possible protection provided by oral quercetin pretreatment against hepatic ischemia-reperfusion injury in rats. METHODS The quercetin (0.13 mmol/kg) was orally administrated in 50 min prior to hepatic ischemia-reperfusion injury. Ascorbic acid was also similarly administered. The hepatic content of quercetin was assayed by high performance liquid chromatography (...

Hepatic stellate cells (HSCs) undergo activation and transdifferentiation to myofibroblast like cells in liver injury, leading to liver fibrosis. During recovery from injury, activated HSCs may either revert back to quiescent state or undergo apoptosis or both. In the present study, we have examined whether recovery from hepatic injury involves apoptosis of activated HSCs and tested whether cur...

conclusions hepatotoxicity of halogenated inhalational anesthetics has been well documented in available literature. halothane-induced liver injury was extensively acknowledged; however, the next generation halogenated anesthetics have different molecular structures and associated with less hepatotoxicity. although anesthesia-induced hepatitis is not a common occurrence, we must consider the as...

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated carbon tetrachloride-induced hepatic injury model Swiss albino mice. Effects the methanolic rhizome extracts (HAME) at a dose 200 mg/kg body weight and 500 tested for its efficacy on CCl4 (1ml/kg weight) induced liver injury. Hepatic toxicity enzyme markers histological parameters were studied. Daily oral administration...

Hepatic ischemia-reperfusion injury (HIRI), which can severely impair liver function, has a potential relationship with reactive nitrogen species. Nitroxyl (HNO) been discovered for its involvements in some biological functions...

The hepatic circulation is unique in that high volumes of low pressure blood flow are supplied through a dual venous and arterial circulation. This vascular supply is modulated both by the gastrointestinal vascular bed and an intrahepatic microcirculation. This complex vascular system is influenced by pathologic processes within the liver. Alterations in the hepatic circulation reflect hepatic ...

In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

Background: Liver ischemia / reperfusion Injury (IRI) is one of the major causes of liver failure during various types of liver surgery, trauma and infections. The present study investigates the effect of dexsamethasone on the liver injury and inducible nitric oxide synthase gene expression during hepatic warm ischemia/reperfusion in rats. Materials and Methods: 24 male Wistar rats (200-250 g)...