Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood. The aim of this study was to investigate the potential protective role of the mesenchymal stem cells (MSCs) and ischemic pr...

Incubation of rat hepatocytes with epinephrine inhibited alanine aminotransferase (ALT) (80%) and aspartate aminotransferase (AST) (53%) activities with no effect on lactate dehydrogenase (LDH) activity. Injection of epinephrine caused a progressive increase with time in hepatic LDH activity, being 52% at 24 h. Preinjection with propranolol eliminated the hormone effect and caused further ...

Hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is an important regulatory enzyme of glucose metabolism. By controlling the level of fructose-2,6-bisphosphate, an allosteric activator of the glycolytic enzyme 6-phosphofructo-1-kinase and an inhibitor of the gluconeogenic enzyme fructose-1,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase regulates hepatic gluco...

background: we tested whether hepatic haemodynamics assessed by doppler ultrasonography can be a predictor of response to therapy in patients with non‑alcoholic fatty liver disease (nafld) to prevent further unnecessary diagnostic tests and interventions. methods: forty eight consecutive patients affected by nafld, who refered to some clinics in tabriz, iran between 2009 and 2011 were included ...

background: the renin-angiotensin system has an important role in hepatic inflammation and fibrosis. renin-angiotensin system blockade by angiotensinconverting enzyme (ace) inhibitors provides some protective effects against hepatic fibrogenesis. captopril as an ace inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (bdl) rats. object...


 Aims: Several parts of medicinal plants have been known to many health benefits. One those is the Crinum glaucum (CG) bulb. Therefore, this research was undertaken investigate therapeutic role an aqueous extract CG bulb (aeCGb) against lipopolysaccharide (LPS)-induced haematological and hepatic enzyme alterations in male female rat models.
 Study Design Methodology: Twenty-five twen...

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated carbon tetrachloride-induced hepatic injury model Swiss albino mice. Effects the methanolic rhizome extracts (HAME) at a dose 200 mg/kg body weight and 500 tested for its efficacy on CCl4 (1ml/kg weight) induced liver injury. Hepatic toxicity enzyme markers histological parameters were studied. Daily oral administration...