Hemorrhagic shock and resuscitation induces pulmonary inflammation that leads to acute lung injury. Biliverdin, a metabolite of heme catabolism, has been shown to have potent cytoprotective, anti-inflammatory, and anti-oxidant effects. This study aimed to examine the effects of intravenous biliverdin administration on lung injury induced by hemorrhagic shock and resuscitation in rats. Biliverdi...

conclusions anesthetic and surgical management was difficult due to the inability to position in supine and rapidly progressing hemorrhagic shock. surgical management for extraction of this iron bar and intensive monitoring and resuscitation resulted in an uneventful successful outcome. introduction penetrating thoracoabdominal injuries are potentially life threatening due to the associated hem...

INTRODUCTION The effect of severe soft tissue injury on the severity of hemorrhagic shock is still unknown. Therefore, the present study was aimed to determine hemodynamic and metabolic changes in traumatic/hemorrhagic shock in an animal model. METHODS Forty male rats were randomly divided into 4 equal groups including sham, hemorrhagic shock, soft tissue injury, and hemorrhagic shock + soft ...

Although 17β-estradiol (E2) treatment following hemorrhagic shock or ischemic reperfusion prevents organs from dysfunction and injury, the precise mechanism remains unknown. We hypothesize that the E2-mediated attenuation of liver injury following hemorrhagic shock and fluid resuscitation occurs via the p38 mitogen-activated protein kinase (MAPK)-dependent heme oxygenase (HO)-1 pathway. After a...

an animal model was designed to study the effect of large volume hypertonic solutions (hts) for re suscitation following a hypovolemic shock. resuscitation in hypovolemic animals was performed by infusion of 15 ml/kg of normal saline (group i), 5% sodium bicarbonate (nahco3) (group ii), 5% sodium chloride (naci) and 7.5 % nahco3 1:1 vn (group iii), 5% nac1 (group iv), and 5% nacl and 5% serum a...

Hemorrhagic shock is a severe life-threatening emergency affecting all organ systems of the body by depriving tissue of sufficient oxygen and nutrients by decreasing cardiac output. This article is a short review of the different types of shock, followed by information specifically referring to hemorrhagic shock. The American College of Surgeons categorized shock into 4 classes: (1) distributiv...

INTRODUCTION To date, there are insufficient data demonstrating the benefits of preclinically administered Ringer-lactate (RL) for the treatment of hemorrhagic shock following trauma. Recent animal experiments have shown that lactate tends to have toxic effects in severe hemorrhagic shock. This study aimed to compare the effects of RL administered in a rat model of severe hemorrhagic shock (mea...

Dengue hemorrhagic fever (DHF) is an acute fabrile illness caused by four serotypes of Dengue virus and characterized clinically by hemorrhagic diathesis and a tendency to develop a shock syndrome (DSS). In the earlier epidemics(l-3), hemorrhagic manifestations and shock were the main features. In the past two years, we have found that neurological manifestations were prominent in addition to s...

Hemorrhagic shock causes myocardial contractile depression. Although this myocardial disorder is associated with increased expression of tumor necrosis factor-alpha (TNF-alpha), the role of TNF-alpha as a myocardial depressant factor in hemorrhagic shock remains to be determined. Moreover, it is unclear which TNF-alpha receptor mediates the myocardial depressive effects of TNF-alpha. Toll-like ...