By Susis W. FONG, ARLENE NUCKTON AND H. H. FUDENBERG M ANY SEROLOGIC tests have been advocated as aids for the antenatal diagnosis of ABO hemolytic disease of the newborn (ABO HDN). The majority of the tests currently used in most hospital clinical laboratories for this purpose make use of certain serologic properties that differentiate the isoagglutinins into two groups. Although both groups p...

The present study attempts to find the role of Haptoglobin in the hemolytic disease of the newborn (HDN) , to ascertain the selective advantage of HP*1 over HP*2 , due to greater binding capacity of hemoglobin of the former; and to find the association of Haptoglobin with ABO blood group system. 71 children (37 – male; 34 – female) with HDN were studied along with their parents. Distribution of...

The Kidd blood group is clinically significant since the Jk antibodies can cause acute and delayed transfusion reactions as well as hemolytic disease of newborn (HDN). In general, HDN due to anti-Jk(b) incompatibility is rare and it usually displays mild clinical symptoms with a favorable prognosis. Yet, we apparently experienced the second case of HDN due to anti-Jk(b) with severe clinical sym...

Background. ABO hemolytic disease of the newborn is the most common hemolytic consequence of maternofetal blood group incompatibility restricted mostly to non-group-O babies of group O mothers with immune anti-A or anti-B antibodies. Aim. We estimated the risk of ABO HDN with view to determining need for routine screening for ABO incompatibility between mother and fetus. Materials and Methods. ...

Gac Méd Méx Vol. 140, Suplemento No. 3, 2004 Rh haemolytic disease of the fetus and newborn (HDN) is a condition in which the lifespan of the infant’s red cells is shortened by the binding of specific IgG Rh antibodies produced by the mother, which transfer across the placenta. The disease begins in intra-uterine life and shows a wide spectrum of severity. Not all D-positive infants born to mot...

RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...