Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common polymorphism and enzymopathy in humans, affecting approximately 400 million people worldwide. It is responsible for various clinical manifestations, including favism, hemolytic anemia, chronic non-spherocytic hemolytic anemia, spontaneous abortion, and neonatal hyperbilirubinemia. Understanding the molecular mechanisms under...

Description Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency that mainly affects the red blood cells (RBCs). A defect in G6PD enzyme leads to the destruction of premature RBCs causing hemolytic anemia because the body can not compensate the destroyed RBCs. Thus, the affected individuals show jaundice (paleness, yellowing of the skin and whites of th...

Motulsky, A. G., and Kampbell-Kraut, J. M. (1961). Population genetics of glucose-6-phosphate-dehydrogenase deficiency of the red cells. Proceedings of Conference on Genetics in Disease, p. 159. Grune and Stratton, New York and London. Shahidi, N. T., and Diamond, L. K. (1959). Enzyme deficiency in erythrocytes in congenital nonspherocytic hemolytic anemia. Pediatrics, 24, 245. Taj-Eldin, S., A...

T HE SELF-LIMITED NATURE of drug-induced hemolytic crises has been effectively demonstrated by Dern and associates1 in American Negroes, and is believed to be a peculiar feature of primaquine sensitivity. It is well known that gbucose-6-phosphate dehydrogenase-(G-6-PD ) deficient states effect also the Caucasian racial group and particularly the Sardinians among whom 15 per cent are affected.2 ...

I N OUR PREVIOUS communications we reported! on a glutathione deficiency existing in eryt hrocytes of persons with a past history of favism or hemolytic anemia due to drugs. This dieficiency seemedi to be familial, since a high proportion of family members of the affected persons also had low glutathione concentrations in their ‘ ‘ Independently, Sansone and! Segni reported low GSH levels in th...

introduction autoimmune haemolytic anemia (aiha) is a complex process characterized by an immune reaction against red blood cell self-antigens. the analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. this paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...

Background: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening and scarce disorder characterized by acute renal failure and disease, non-immune microangiopathic hemolytic anemia and thrombocytopenia, leading to end-stage renal failure or death, and consequently maybe accompanying by extra renal manifestations. Case report: We reported aHUS accompanied by autoimmune hemolytic anemi...

introduction methylene blue was first described for the treatment of methemoglobinemia but practical usage of the compound for surgical purpose is common. the aim of this report is to describe a case of hemolysis in neonatal period as a potential hazard of methylene blue toxicity without presence of g6pd deficiency. case presentation in october 2015, a 36-week ga female infant with 2.05 kg weig...

abstract background: occupational exposure studies indicate that formaldehyde exposure causes temporary and consistent effects on industrial workers exposed to formalin. case: the case was a 36-year-old man who had developed intravascular hemolytic anemia caused by formalin after inhalation exposure. formalin is a clear solution of 37% formaldehyde in water. the primary route of exposure to for...