Background The purpose of the work was to assess the contribution to diagnosis and/or treatment (CDT) of bone marrow aspiration (BMA) in the critically ill patient. Methods The retrospective study included 193 patients. On the basis of BMA findings, contribution to diagnosis was defined by one of four previously unestablished diagnoses (maturation arrest of granulocyte precursors, hemophagocy...

Erik Ahlstrand (2013): Coagulase-negative Staphylococci in Hematological Malignancy. Örebro Studies in Medicine 95. Bacterial infections are common in hematological malignancy. Coagulasenegative staphylococci (CoNS) are among the most prevalent causes of bacteremia in patients with hematological malignancies. In this thesis, different aspects of CoNS in hematological malignancy have been studie...

The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and c...

Correspondence: Ass. Professor Paraskevi Roussou, 3rd University Department of Medicine, “Sotiria” Hospital, 152 Mesogion Avenue, Athens GR-11527, Greece. Fax: international +301-7719981. A56-year-old woman was referred to us complaining of painful subcutaneous nodules in the lower extremities during the last three months. The nodules appeared a year ago. The physical examination disclosed palp...

Nonmyeloablative stem cell transplantation (NST) is increasingly used with beneficial effects because it can be applied to older patients with hematological malignancies and those with various complications who are not suitable for conventional myeloablative stem cell transplantation (CST). Various conditioning regimens differ in their myeloablative and immunosuppressive intensity. Regardless o...