Introduction: Cupping therapy (hejamat) is one of the therapeutic methods used in traditional medicine that it is still common in many of the contemporary societies. In spite of the progress of science, we have less information on the traditional and alternative medicine including cupping.   With the study of mechanism of action of cupping, it will be more convincing for the traditional medic...

Delayed diagnosis of hematological malignancies in immunocompetent patients with fever of unknown origin (FUO) remains an exhausting challenge for non-hematologist physicians. This retrospective cohort study aimed to establish a scoring system, "bone marrow (BM) score", to identify FUO patients who require early bone marrow biopsy (BMB) to diagnose hematological disease. Two cohorts, comprising...

Cellular components of the blood reflect specific changes in an organ or body system or more often, a general response of the individual to some physiological or pathological conditions. In this chapter, we will review the main physiological factors that should be considered when interpreting equine hematological profiles. The interpretation of the hematological profile in conjunction with hist...

Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalize...

There are a growing number of studies documenting that, similarly to patients with solid cancers, also patients with hematological malignancies (i.e., acute leukemia, lymphoproliferative and myeloproliferative neoplasms and plasma cell disorders) are at increased risk of thrombosis. The pathogenesis of the hypercoagulable state associated with hematological cancers is often multifactorial. Cont...

Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study was conducted to determine the gender and age-specific hematological reference intervals of healthy...

The tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion, and metastasis by providing survival signals and a sanctuary site for tumor cells, by secretion of growth factors, pro-angiogenesis factors and direct adhesion molecule interactions. Our knowledge of microenvironment is only now beginning to unfold. In this review, the morphological and molecular chara...

abstract background: thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by β-thalassemia major. the aim of this case-control study was evaluation of hematological parameters, oxidative str...