Six cases are described of veno-occlusive disease (VOD) after medicinal herb ingestion. The herb Heliotropium eichwaldii, taken by three patients, was found to contain the toxic pyrrolizidine alkaloid, heliotrine. Two patients presented with fulminant hepatic failure while the other four patients had a clinical picture suggestive of decompensated cirrhosis. The medical use of this herb may poss...

Background and objectives: The plants belonging to the genus Heliotropium L. (Boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (PAs). In the present study, we have investigated the PAs of the aerial parts of Heliotropium transoxanum Bunge, a perennial species native to Iran. Methods: Silica gel column chromatography and silica gel PTLC were applied ...

Heliotropium indicum Linn., commonly known as ‘Indian heliotrope’, is a herb with pale violet flowers belonging to the family Boraginaceae and is very common in India with a long history of traditional medicinal uses in many countries in the world. It is distributed in the tropical and temperate regions of the world and found throughout India. The plant is reported to possess antibacterial, ant...

The UHPLC-QToF-MS analysis of pyrrolizidine alkaloids (PAs) from various parts of 37 botanicals and 7 products was performed. A separation by LC was achieved using a reversed-phase column and a gradient of water/acetonitrile each containing formic acid as the mobile phase. MS-MS detection was used because of its high selectivity, and ability to provide structural information. Free base and N-ox...

Under experimental conditions, the effect of plant proanthocyanidin – yantacin isolated from a camel thorn (Alhagi pseudalhagi) Yantacin, when administered orally at dose 100 mg / kg, on possible changes in early stages liver fibrosis that occurred against background chronic heliotrine hepatitis was studied. The studies were conducted male rats with body weight ±10 g. general and biochemical pa...