Proteasome inhibitors such as bortezomib are highly active in multiple myeloma by affecting signaling cascades and leading to a toxic buildup of misfolded proteins. Bortezomib-treated cells activate the cytoprotective heat shock response (HSR), including upregulation of heat shock proteins (HSPs). Here we inhibited the bortezomib-induced HSR by silencing its master regulator, Heat Shock Factor ...

direct restoration of severely damaged endodontically treated teeth (ett) using available and conventional and current matrix systems is sometimes impractical and in some clinical cases is impossible. the aim of this paper is to introduce and describe a new matrix system based on rigid tray technique (rtt) for dealing with such difficult clinical cases.

exposure buildup factors have been calculated by monte carlo method for point isotropic gamma ray sources, penetrating a two-layer spherical shield of water surrounded by lead, and the effect of bremsstrahlung radiation on buildup factors has, in particular, been investigated, the results of which are in good agreement with previous works. the buildup factors were then calculated for various co...

The El Niño-Southern Oscillation (ENSO) has significant impact on global climate and relevance for seasonal forecasts. Recently, a simple modeling framework was developed that captures the ENSO diversity, where statedependent stochastic wind bursts and nonlinear advection of sea surface temperature are coupled to a simple ocean-atmosphere model that is otherwise deterministic, linear and stable...

Introduction: Radiotherapy is one of the effective methods in the treatment of cancer. In the recent methods of radiotherapy, intensity modulated radiotherapy (IMRT) technique by compensators is used. when photon beam passes the compensator, scattered photons can be generated within the compensator. The presence of scattered photons may complicate the design of compensators as...

INTRODUCTION Running gasoline engines in a confined space causes heat stress and carbon monoxide (CO) buildup. Loading the C-130 aircraft by driving the vehicles onto the platform may expose the C-130 cabin crew to these environmental hazards. This study was aimed at investigating heat stress and CO exposure in the C-130 cabin during vehicle airlift. METHODS There were four summer flights (tw...

The Protocol specifically mentions emissions from sources and removals by sinks resulting from direct human-induced land-use change and forest related activities – deforestation, reforestation and afforestation – undertaken since 1990. However, the Protocol is silent on the role of other sinks in meeting national emission inventories. Agricultural land, for example, is mentioned as a possible c...