Background: Heartburn occurs predominantly in the upper gastrointestinal tract and is associated with gastroesophageal reflux disease (GERD) gastritis. Omeprazole most prescribed proton pump inhibitor class of medication to treat heartburn related clinical conditions. To compare efficacy omeprazole 40 mg (as a total daily dose) 20 using patient-reported outcome measures (PROMs) patients due var...

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in esophagus. Mechanisms peripheral and central sensitization their relation to heartburn symptoms are covered detail. Diagnostic criteria algorithms for non-erosive reflux disease, functional heartburn, esophagus based pH-impedance testing high-resolution esophageal manometry data presented.

Heartburn occurs in the presence as well as the absence of acid reflux. We searched for a motor correlate of heartburn. Twelve subjects with heartburn were studied with 24-h synchronized pressure, pH, and high-frequency intraluminal ultrasound (HFIUS) imaging of the esophagus. The HFIUS images were analyzed every 2 s for a period of 2 min before and 30 s after the onset of heartburn during 20 a...

Heartburn, the main symptom of gastrooesophageal reflux disease (GORD), might be expected to occur infrequently in achalasia, a disorder characterised by a hypertensive lower oesophageal sphincter (LOS) that fails to relax. Nevertheless, it is often described by patients with achalasia. The medical records of 32 patients with untreated achalasia who complained of heartburn, and of 35 similar pa...

BACKGROUND Patients with gastro-oesophageal reflux disease (GORD) frequently report that meals high in fat worsen heartburn. Nevertheless, studies to determine whether high fat meals promote gastro-oesophageal reflux have produced conflicting and equivocal conclusions. PATIENTS AND METHODS To determine, alternatively, whether fat in the small intestinal lumen intensifies the perception of hea...

Severity and frequency of gastroesophageal reflux disease (GERD) related symptoms are associated with impaired health-related quality of life (HRQL). This study evaluated the association between baseline heartburn severity and endpoint HRQL of patients treated for heartburn and the relationship between complete resolution of heartburn symptoms and HRQL outcomes after controlling for baseline se...