H eard et al (2015) generated cIap1 / Xiap / mice and were surprised to find them to be viable and fertile, because we had reported (Moulin et al, 2012) that cIap1 / Xiap / mice died by day E12.5 of embryogenesis (Moulin et al, 2012 Figs 1B and 2B and Supplementary Fig S1A). We are working with Heard et al (2015) in an attempt to determine why. It is, however, clear that failure of our cIap2cIa...