Metaphysis cancellous bone fracture is one of the most common fracture types in clinical orthopedic practice. The specialized healing process of cancellous bone fracture has long been ignored by the academic society. Comparing with diaphyseal cortical bone healing, cancellous bone healing showed less bone tissue necrosis, barely any hematoma formation, limited inflammation events and no externa...

bone loss after spinal cord injury leads to increased fragility of bone and subsequent risk for low-trauma fractures in the sublesional parts of the body . although in such injuries upper limbs are normally innervated, bone loss may occur in the upper extremities. the present study was designed to determine the systemic effects of spinal cord injury on the fracture healing of upper limbs in rab...

Bone loss and skeletal fragility in bone fracture are caused by an imbalance in bone remodeling. The current challenge in bone fracture healing is to promote osteoblastogenesis and bone formation. We aimed to explore the role of IL-20 in osteoblastogenesis, osteoblast differentiation and bone fracture. Serum IL-20 was significantly correlated with serum sclerostin in patients with bone fracture...

Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be crucial for fracture healing, because it may induce down-stream responses leading to tissue repair. However, the impact of the immune response o...

Bone loss after spinal cord injury leads to increased fragility of bone and subsequent risk for low-trauma fractures in the sublesional parts of the body. Although in such injuries upper limbs are normally innervated, bone loss may occur in the upper extremities. The present study was designed to determine the systemic effects of spinal cord injury on the fracture healing of upper limbs in rabb...

low-intensity laser therapy (lilt) is defined to supply direct biostimulative light energy to the cells. while several studies have demonstrated that lilt has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or no effects after lilt. the aim of this article was to review the studies evaluating the biomodulation effects...

Bisphosphonates (BPs) have been in use for many years for the treatment of osteoporosis, multiple myeloma, Paget's disease, as well as a variety of other diseases in which there is reduced bone mineral density. Given that bisphosphonates inhibit bone resorption, an important stage of fracture healing; this class of compounds has been widely studied in preclinical models regarding their influenc...

The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts. C5aR1 induces osteoblast migration, cytokine generation and osteoclastogenesis, however, the exact role of C5aR1-mediated signaling in osteoblasts is not entirely kn...

BACKGROUND Melatonin, the major pineal hormone, is known to regulate distinct physiologic processes. Previous studies have suggested that it supports skeletal growth and bone formation, most probably by inhibiting bone resorption. There is no information, however, whether melatonin affects fracture healing. We therefore studied in a mouse femur fracture model the influence of melatonin on callu...