➤ There are a number of potential clinical applications for growth factors in the enhancement of bone repair, including acceleration of fracture-healing, treatment of established nonunions, enhancement of primary spinal fusion or treatment of established pseudarthrosis of the spine, and as one element of a comprehensive tissueengineering strategy that could include gene therapy to treat large b...

Although the success story of surgical fracture treatment led to a tremendous improvement outcome for certain fractures such as femur or tibia shaft fractures, overall benefit versus conservative remains controversial several types fractures. For this sake, we carried out narrative review high-level evidence studies comparing outcomes in with debates on value therapy clavicle, proximal humerus,...

Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loa...

In a previous study, we isolated human amniotic fluid (AF)-derived mesenchymal stem cells (AF-MSCs) and utilized normoxic conditioned medium (AF-MSC-norCM) which has been shown to accelerate cutaneous wound healing. Because hypoxia enhances the wound healing function of mesenchymal stem cell-conditioned medium (MSC-CM), it is interesting to explore the mechanism responsible for the enhancement ...

Self-healing cementitious materials with microcapsules are complex multiscale and multiphase materials. The random microstructure of these governs their mechanical transport behaviour. actual can be represented accurately a discrete lattice model, but computational restrictions mean that the size domain considered this approach is limited. By contrast, smeared approach, based on micromechanical...

OBJECTIVES We sought to determine the relationship of delayed hyperenhancement by contrast magnetic resonance imaging (MRI) to viable and nonviable myocardium within the region at risk throughout infarct healing. BACKGROUND The relationship of delayed MRI contrast enhancement patterns to injured but viable myocardium within the ischemic bed at risk has not been established. METHODS We compa...

OBJECTIVE To determine the surgical outcome of patients with axial cervical spine fractures. METHODS The randomised double-blinded placebo-controlled clinical study was conducted at the Indus Hospital, Karachi, from August 2011 to August 2013. Patients were randomised to receive placebo or strontium ranelate postoperatively after surgical fixation of tibial diaphyseal fractures. Assessment of...