INTRODUCTION AND EPIDEMIOLOGY Heartburn, or pyrosis, is usually described as a burning sensation that radiates upward retrosternally from the epigastrium toward the neck. Heartburn is a common symptom that occurs frequently during pregnancy, in any trimester. Although “heartburn” and “gastroesophageal reflux disease (GERD)” have become integrally connected in the medical literature, the two ter...

Heartburn, the main symptom of gastrooesophageal reflux disease (GORD), might be expected to occur infrequently in achalasia, a disorder characterised by a hypertensive lower oesophageal sphincter (LOS) that fails to relax. Nevertheless, it is often described by patients with achalasia. The medical records of 32 patients with untreated achalasia who complained of heartburn, and of 35 similar pa...

The aim of this study was to compare the therapeutic efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy. A double-blinded, randomized, controlled trial was conducted. One hundred pregnant women at less than 36 weeks gestation with heartburn at least twice per week were randomized to either alginate-based reflux suppressant o...

Background: Heartburn occurs predominantly in the upper gastrointestinal tract and is associated with gastroesophageal reflux disease (GERD) gastritis. Omeprazole most prescribed proton pump inhibitor class of medication to treat heartburn related clinical conditions. To compare efficacy omeprazole 40 mg (as a total daily dose) 20 using patient-reported outcome measures (PROMs) patients due var...

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in esophagus. Mechanisms peripheral and central sensitization their relation to heartburn symptoms are covered detail. Diagnostic criteria algorithms for non-erosive reflux disease, functional heartburn, esophagus based pH-impedance testing high-resolution esophageal manometry data presented.

Heartburn occurs in the presence as well as the absence of acid reflux. We searched for a motor correlate of heartburn. Twelve subjects with heartburn were studied with 24-h synchronized pressure, pH, and high-frequency intraluminal ultrasound (HFIUS) imaging of the esophagus. The HFIUS images were analyzed every 2 s for a period of 2 min before and 30 s after the onset of heartburn during 20 a...

Introduction: Millions of Muslims across the world observe Islamic fasting during the holy month of Ramadan, as well as the other specific dates in the lunar calendar year. While fasting during this month, Muslims refrain from eating or drinking from dawn to dusk. Islamic fasting is similar to alternate day fasting (ADF) since it incorporates an average of 12 hours of fasting and 12 hours of fe...