Background/AimsPrimary hepatocellular carcinoma (HCC) is one of the most lethal tumor diseases in world. Receptor tyrosine kinases (RTKs) are thought to play a vital role HCC and Ephrin-A4 ligand (EFNA4) membrane-bound molecule that can activate RTKs through erythropoietin-producing (Eph) receptors. However, specific EFNA4 remains unknown. The aim our study was explore prognostic value expressi...

CircRNAs are crucial in tumorigenesis and metastasis, comprehensively downregulated hepatocellular carcinoma (HCC). Previous studies demonstrated that the back-splicing of circRNAs was closely related to 3′-end splicing. As a core executor cleavage, we hypothesized CPSF3 modulated circRNA circularization. Clinical data were analyzed establish prognostic correlations. Cytological experiments per...

This study intends to explore the effects of microRNA-126 (miR-126) on cell proliferation, apoptosis, and tumor angiogenesis in hepatocellular carcinoma (HCC) by regulating epidermal growth factor-like domain 7 (EGFL7) through extracellular signal-regulated kinase (ERK) signaling. HCC tissues and adjacent normal tissues were obtained from 184 HCC patients. HCC cells were separately transfected ...

AMP-activated protein kinase (AMPK) is a central metabolic sensor and plays an important role in regulating glucose, lipid and cholesterol metabolism. Therefore, AMPK is a key therapeutic target in diabetes. Recent pilot studies have suggested that diabetes drugs may reduce the risk of cancer by affecting the AMPK pathway. However, the association between AMPK and the proliferation of hepatocel...

Mitochondria are highly dynamic and undergo constant fusion and fission that are essential for maintaining physiological functions of cells. Recently, we have reported that increased mitochondrial fission promotes autophagy and apoptosis resistance in hepatocellular carcinoma (HCC) cell through ROS-mediated coordinated regulation of NF-κB and p53 pathways. However, little is known about the rol...

Abstract Background Metabolic dysregulation is one of the hallmarks tumor cell proliferation. Evidence indicates potential role 5′adenosine monophosphate-activated protein kinase (AMPK) and B/Akt signaling pathway in regulating proliferation, survival, apoptosis. The present study explores effect metformin HCl combination α- β-asarone on proliferation HepG2 cells presence high glucose levels si...

BACKGROUND BTG3 (B-cell translocation gene 3) has been identified as a tumor suppressor and hypermethylation contributes to its down-regulation in some tumors, but its role in hepatocellular carcinoma (HCC) remain unknown. This study aimed to detect the expression and methylation status of BTG3 in HCC cell lines or tissues, and determine its function in HCC progression. METHODOLOGY The expres...

Qilian Huaji Decoction (QLHJD) is a mixture of 13 herbs. The aim this study to observe the efficacy QLHJD against hepatocellular carcinoma (HCC). H22 transplanted mouse models were established explore effect on HCC in vivo. QLHJD-containing serum (QCS) was prepared using traditional Chinese medicine pharmacology methods. After QCS treatment, cell proliferation, cycle and apoptosis HepG2 cells a...

background the mutations of lhbs in pre-s, especially in pre-s2, are definitive in hepatocellular carcinoma (hcc) associated with hbv. however, the mechanisms of the n-glycosylation modification in lhbs are unclear. the n-glycosylation modification of lhbs affects endoplasmic reticulum stress, cell proliferation and its secretion which was further studied. objectives the objectives of our studi...

BACKGROUND/AIMS The pathogenesis of hepatocellular carcinoma (HCC) is mainly characterized by persistent cycles of liver injury, inflammation, and compensatory hepatocyte proliferation. Angiotensin II (Ang II) behaves as an endogenous pro-inflammatory molecule playing a significant role in HCC, however, the molecular link between Ang II, proliferation and inflammation remains unclear. METHODS...