BACKGROUND Triple-course vaccination against hepatitis B might sometimes fail to increase antibody titers or maintain it at sufficient levels. The aim of this study was to evaluate the rate of seroprotection in dental students after receiving recombinant hepatitis B vaccine. METHODS Anti-HBs levels of 124 dental students who had received triple-course hepatitis B vaccines (scheduled at months...

OBJECTIVE The aim of this study was to assess the antibody response to combined passive-active immunization versus active immunization against hepatitis B in 71 patients with acute leukemia with negative hepatitis B virus serology at presentation. METHODS The first group (n=28) received a double dose of hepatitis B vaccine at 0, 1, 2 and 6 months and immunoglobin (HBIG) at 0 and 1 month concu...

Long-term immunoprophylaxis with anti-HBs immunoglobulins (HBIg) is used to prevent hepatitis B (HBV) reinfection after liver transplantation for HBV-related cirrhosis. This approach is highly expensive. A recent report proposed posttransplant HBV vaccination with a reinforced schedule as an alternative strategy to allow HBIg discontinuation. We investigated the efficacy of a reinforced triple ...

Background: There is a controversy about the relation between anti-hepatitis B (anti-HBs) antibody level and obesity. We designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. Methods: In this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. Cases were selected from a referral clinic for obesity and a referral hepa...

Result 85 samples from health care workers who had needle stick injury were processed .The samples were from doctors (38%), nurses (20%), technicians (7%), housekeeping staff (23 %), and students (10%). All the samples of injured persons were found seronegative by both methods, anti-HBs titer was found to be protective. Conclusion Strict HBV vaccination program and monitoring the anti-HBs titer...

HBs protein is encoded by the pre-S and S genome, and the detection of HBs antigen (HBsAg) in sera is an initial step for the diagnosis of hepatitis B virus (HBV) infection. The “a” determinant region (amino acid residues 124–147) is the main epitope for inducing a protective immune response. Mutations in the “a” determinant region, known as escape mutants, affect antigenicity and hinder attemp...

background although recombinant hepatitis b vaccine is effective in a majority of population, a significant percent may do not response (up to 10%). old age, obesity, heavy smoking and immunologic impairment have been associated with lower anti –hbs responses. in the present study, the efficacy of vaccine and effects of the abovementioned factors have been evaluated. materials and methods of 11...