A large protein machinery is required for 3'-end processing of mRNA precursors in eukaryotes. Cleavage factor IA (CF IA), a complex in the 3'-end processing machinery in yeast, contains four subunits, Rna14, Rna15, Clp1, and Pcf11. Rna14 has a HAT (half a TPR) domain at the N terminus and a region at the C terminus that mediates interactions with Rna15. Rna15 contains a RNA recognition module (...

The aim of this study is to investigate the improvement in strength a top-hat profile hollow-section beam used vehicle structure by attaching different shapes internal reinforcements. base was first considered as hat-shape which jointed flat plate using spot-welds. Three types sheet metal reinforcements were formed and attached inside beam’s structure. Then, they tested experimentally under low...

Reactions of Fe(II) salts with the ligand 1,4,5,8,9,12-hexaazatriphenylene (HAT) led to the isolation and characterization of four new compounds: [Fe3(HAT)(H2O)12](SO4)3.3.3H2O (1), [Fe2(HAT)(SO4)(H2O)5](SO4).2H2O.CH3OH (2), [Fe2(HAT)(SO4)(H2O)5](SO4).3H2O (3), and [Fe3Cl5(HAT)(CH3OH)4(H2O)]Cl (4). Compound 1 crystallizes as a trinuclear cluster in which HAT acts as a tris-chelating ligand. Com...

‎in 1970‎, ‎menegazzo [gruppi nei quali ogni sottogruppo e intersezione di sottogruppi massimali‎, ‎ atti accad‎. ‎naz‎. ‎lincei rend‎. ‎cl‎. ‎sci‎. ‎fis‎. ‎mat‎. ‎natur. 48 (1970)‎, ‎559--562.] gave a complete description of the structure of soluble $im$-groups‎, ‎i.e.‎, ‎groups in which every subgroup can be obtained as intersection of maximal subgroups‎. ‎a group $g$ is said to have the $fm$...

Reactions of Cu I salts with 1,4,5,8,9,12-hexaazatriphenylene (HAT) afford three types of cationic coordination polymers depending on the anion present in the reaction solution. In the crystal structure of {[Cu(HAT)][BF4]x1/3(C6H6)}infinity, (1), Cu ions and HAT molecules form extended layers that are best described as strongly distorted honeycomb nets. The space between the layers is occupied ...

The half-a-tetratricopeptide (HAT) repeat motif is of interest because it is found exclusively in proteins that are involved in RNA metabolism. Little is known about structure-function relationships in this class of repeat motif. Here, we present the results of a combined bioinformatics, modeling and mutagenesis study of the HAT domain of Utp6. We have derived a new HAT consensus, delineated it...

To explore the impact of global incorporation of fluorinated aromatic amino acids on protein function, we investigated the effects of three monofluorinated phenylalanine analogs para-fluorophenylalanine (pFF), meta-fluorophenylalanine (mFF), and ortho-fluorophenylalanine (oFF) on the stability and enzymatic activity of the histone acetyltransferase (HAT), tGCN5. We selected this set of fluorina...

Histone acetyltransferases (HATs) use acetyl CoA to acetylate target lysine residues within histones and other transcription factors, such as the p53 tumor suppressor, to promote gene activation. HAT enzymes fall into subfamilies with divergence in sequence and substrate preference. Several HAT proteins have been implicated in human cancer. We have previously reported on the preparation of pept...

A cylindrical hat-loaded method is employed to make monopoles behave as dual band resonators. The two frequency bands are obtained by perturbing higher propagation modes by modifying the hat length. The longer the cylindrical hat is, the lower the resonant frequencies are obtained. The hat length behaves as an inductive load, also increasing the electric length of the monopole. As a result, a c...

‎In 1970‎, ‎Menegazzo [Gruppi nei quali ogni sottogruppo e intersezione di sottogruppi massimali‎, ‎ Atti Accad‎. ‎Naz‎. ‎Lincei Rend‎. ‎Cl‎. ‎Sci‎. ‎Fis‎. ‎Mat‎. ‎Natur. 48 (1970)‎, ‎559--562.] gave a complete description of the structure of soluble $IM$-groups‎, ‎i.e.‎, ‎groups in which every subgroup can be obtained as intersection of maximal subgroups‎. ‎A group $G$ is said to have the $FM$...