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PURPOSE We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease. EXPERIMENTAL DESIGN Men with measurable metastatic disease received one vaccine injection. Toxicity, immune responses, changes in PSA doubling times, and patient survival were assessed. Thirty-two patients with hormone-refractory met...

Immunotherapies for cancer are transforming patient care, but clinical responses vary considerably from patient to patient. Simple, inexpensive strategies to target treatment to likely responders could substantially improve efficacy while simultaneously reducing health care costs, but identification of reliable biomarkers has proven challenging. Previously, we found that pre-treatment serum IgM...

risalat risalat al-ghofran is the letter that abu ala marri (363-449 ah) writes in response to a letter from ali ben mansour halabi. inspired by the story of his ascension and the quran makes for a very long introduction to this thesis imaginary journey to heaven and hell are brought into the picture and verses and poems, and news and conflict in many lexical and syntactic text instead gives it...

The act of helping is a way of sharing information and expertise, a means of redistributing wealth, and the primary tool by which people take care of less fortunate others. We often do this, as a society, out of genuine empathic concern for others (Batson, 1994), sometimes augmented by reciprocity beliefs (Eisenberger, Armeli, Rexwinkel, Lynch, & Rhoades, 2001; Hardy & van Vugt, 2006). Recently...

You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) II (MP24)1 Sep 2021MP24-05 LONG-TERM FOLLOW-UP AND PROGNOSTIC FACTOR ANALYSIS IN MEN WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER (MCRPC) WHO RECEIVE PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)-TARGETED LUTETIUM-177 (177LU) Michael Sun, Charlene Thomas, Benedict Ho, Junaid Niaz, Jones Nauseef, Joseph Osbor...

the thought of leaving this world for the heavens, paradise and hell inspired by the holy prophet’s ascension appeared in the form of fictional stories in the arabic literature in the fifth century (solar calendar), i.e. in the late abbasid period, although the history of such journeys goes back to the time before islam. as it goes in pahlavi texts, the first one to have gone on oneiric journey...

PURPOSE There is evidence that therapeutic cancer vaccines can lengthen survival for some patients with cancer, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. EXPERIMENTAL DESIGN This retrospective study included 141 subjects from phase II trials of PROST...

Privacy and Security have become an indispensable matter of attention in the Vehicular Ad-Hoc Network, which is vulnerable to many security threats these days. One of them is the Denial of Service (DoS) attacks, where a malicious node forges a large number of fake identities, i.e., Internet Protocol (IP) addresses in order to disrupt the proper functioning of fair data transfer between two fast...