The stoichiometric reaction of para-methoxyanilines and B(C6F5)3 under H2 results in reduction of the N-bound phenyl ring(s), and subsequent transannular ring closure with elimination of methanol, affording the respective 7-azabicyclo[2.2.1]heptane derivatives.

This paper examines the unimolecular dissociation of propargyl (HCCCH2) radicals over a range of internal energies to probe the CH+HCCH and C+C2H3 bimolecular reactions from the radical intermediate to products. The propargyl radical was produced by 157 nm photolysis of propargyl chloride in crossed laser-molecular beam scattering experiments. The H-loss and H2 elimination channels of the nasce...

This study examines a variety of compounds containing silicon-phosphorus multiple bonds as well as a selection of hydrogen-bridged species, including a doubly bridged structure. The structures of 29 minima and 37 transition states of the form Si2PHn (n ) 7, 5, 3, 1) have been optimized at the MP2(full)/6-31G(d) level of theory; a representative subset was also optimized at the QCISD/6-311G(d,p)...

Summary The advent of transfer hydrogenation and borrowing hydrogen reactions paved the way to manipulate simple alcohols in previously unthinkable manners circumvented need for gas. Analogously, hydrocarbylation could greatly increase versatility tertiary alcohols. However, this reaction remains unexplored because challenges associated with catalytic cleavage unactivated C–C bonds. He...

the H2 reductive-elimination process of importance to homogeneous and heterogeneous hydrogenation catalysis, the isotope effect observed supports the model of a late transition state where the H-H bond forms nearly completely either in the transition state or in a metastable q2-H2 intermediate. The relatively low (10-20 kcal/mole) enthalpies of activation for hydrogen reductive elimination for ...

The medicinal value of hydrogen (H2) was ignored prior to research illustrating that inhalation of 2% H2 can significantly decrease the damage of cerebral ischemia/reperfusion caused by oxidative stress via selective elimination of hydroxyl freebase (OH) and peroxynitrite anion (ONOO-). Subsequently, there have been numerous experiments on H2. Most research and trials involving the mechanisms u...

Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic sequences (H1, H2, and H3) and an acidic region, targets and anchors perilipins to lipid droplets. Thus, we hypothesized that H1, H2, and H3 are targeting and anchoring motifs. We now show that deletion of any single hydrophobic sequence or combinati...