Background: Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Myrica sapida is known traditionally in...

protection of animals immunized against bacillus anthracis is usually demonstrated by challenging with an appropriate dose of a strain of bacillus anthracis that is lethal to unvaccinated animals inoculated at the same time. in this study the protective efficacy in anthrax vaccine (34f2 sterne strain spore) was evaluated in sheep, goats and guinea pigs challenged with subcutaneous inoculation o...

Objective: The effects of natural adjuvants were examined on total and differential WBC counts in lung lavage of sensitized guinea pigs. Materials and Methods: In three sensitized groups of guinea pigs including: untreated sensitized animals (S), sensitized animals treated with adjuvant G2 (S+G2) and G2F (S+G2F) as well as non-sensitized group (C) (n=6 for each group), total and differential WB...

  Objective(s): The effect of the extract of Crocus sativus and its constituent, safranal on inflammatory markers in sensitized guinea pigs was examined.   Materials and Methods: Ovalbumin (OA) sensitized guinea pigs were given drinking water alone (group S), or drinking water containing three concentrations of safranal, three concentrations of extract and one concentration of dexamethasone, (n...

foot-and-mouth disease (fmd) is a severely contagious viral disease that mainly affects cloven-hoofedlivestock and wildlife. this study quantifies the cytokines mrna expression of vaccinated guinea pigs withfmd type o inactivated vaccine. blood samples were collected from eight guinea pigs at 7 and 28 days after thefirst vaccination. extracted mrnas were reverse-transcribed into cdna and analyz...

Background: Exposure to ionizing radiation is known to have various effects on hematological parameters of biological sample. This study was aimed at evaluating the effect of ionizing radiation on some hematological parameters in guinea pigs. Materials and Methods: Thirty-six (36) apparently healthy adult guinea pigs of both sexes weighing between 700g – 1200...

Objective: Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated. Materials and Methods: Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentration...

objective: pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. in this study the effects of carvacrol on serum levels of total protein (tp), phospholipase a2 (pla2) and histamine in sensitized guinea pigs was evaluated. materials and methods: sensitized guinea pigs were given drinking water alone (group s), drinking water containing three concentration...

Acetamiprid (ACP) belonging to the neonicotinoid family used against wide array of pests in agriculture and domestic purposes. In this study, we evaluated the attenuating effects of ethanolic extract of Mangifera indica leaves (EEMI) in averting reproductive toxicity caused by ACP in male guinea pigs. Thirty male guinea pigs were randomly assigned to five treatment groups (n = 6). Grou...

weed pollen grains belonging to  the  asteraceae  family contain  a variety of  allergens inducing type i  and iv allergies in susceptible people. the  aim of this research was to compare  the  allergenic properties  of  immature  and  mature  shasta  daisy pollen  grains (chrysanthemum maximum ramond) to define the potential role of the maturation process on the allergenicity of asteraceae pol...