borrelia microtti and borrelia persica are two iranian strains of spirochetes whose vectors are ornithodorous tholozani and ornithodorous erraticus which are responsible for relapsing fever. bsk medium has been used for in vitro culture of other strains of borrelia, although the two mentioned strains could not be successfully cultured in it. we have modified bsk medium by using guinea pig and f...

background : animal models have been proven useful in elucidating the details of interaction between pathogenic bacteria and their human hosts, in addition to assessing the efficacy of therapeutic compounds and vaccines. in this study, we investigate the colonization of helicobacter pylori ( h. pylori ) in experimentally-infected guinea pigs over a six-month period. materials and methods: a bac...

esophagus having different tissues has a special role in the gastrointestinal tract. among different species, layers of the esophagus, have a substantial difference. also, diameter of esophagus varies in different parts of it.the information of histological structure of rabbit and guinea pig esophagus is still incomplete. therefore, the present study was conducted. therefore, for review and com...

several therapeutic effects including diuretic, anti-pyretic and anti-scurvy have been reported for portulaca oleracea. in previous studies the analgesic, anti-inflammatory, anti-hypertensive, anti-oxidant, muscle relaxant effects and neuropharmacological effects of the aqueous extract of portulaca oleracea have been demonstrated on experimental animals. in the present study the antitussive eff...

objective(s) in the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of rosa damascena on tracheal smooth muscle of guinea pigs were examined. materials and methods the relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0....

objectives: cow urine ark (cua), known as “amrita” as mentioned in ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. therefore, we designed the present study to evaluate the lipid ‎lowering activity of cua and its possible implication in metabolic syndrome.‎ materials and methods: thirty guinea pigs of either sex were divided into five groups: group 1 and 2 serving as a vehicle ‎a...

foot-and-mouth disease (fmd) is a severely contagious viral disease that mainly affects cloven-hoofedlivestock and wildlife. this study quantifies the cytokines mrna expression of vaccinated guinea pigs withfmd type o inactivated vaccine. blood samples were collected from eight guinea pigs at 7 and 28 days after thefirst vaccination. extracted mrnas were reverse-transcribed into cdna and analyz...

Onion (Allium Cepa) contains high levels of flavonoids. Although there are many studies indicating the inhibitory effects of flavonoids on xanthine oxidase, there is no report on the effect of onion on this enzyme. Therefore, in the present study, the inhibitory effects of onion on xanthine oxidase are investigated. Fresh filtered juice of onion was prepared and its inhibitory effect on guine...

Background: Fibroblast cell lines have different application in biological research including nuclear transfer in cloning, feeder layer of embryonic stem cells, wound healing research and tissue engineering. The objective of the present study was to determine the proper pregnancy age for collecting and culturing guinea pig fetal fibroblast. Materials and Methods: Guinea pig fetuses were collect...

flavonoids could serve as potent inhibitors of xanthine oxidase (xo). in the present study, the effects of ruta graveolens l. extract and its major isolated flavonoids, quercetin and rutin, on guinea pig liver xo have been investigated. the inhibitory effects of r. graveolens, quercetin and its glycoside form, rutin, were assayed spectrophotometrically. r. graveolens extract showed moderate inh...