نتایج جستجو برای: gspe

تعداد نتایج: 87  

Journal: :Free radical biology & medicine 2002
Savita Khanna Mika Venojarvi Sashwati Roy Nidhi Sharma Prashant Trikha Debasis Bagchi Manashi Bagchi Chandan K Sen

Angiogenesis plays a central role in wound healing. Among many known growth factors, vascular endothelial growth factor (VEGF) is believed to be the most prevalent, efficacious, and long-term signal that is known to stimulate angiogenesis in wounds. The wound site is rich in oxidants, such as hydrogen peroxide, mostly contributed by neutrophils and macrophages. We proposed that oxidants in the ...

Journal: :EMBO reports 2001
B Py L Loiseau F Barras

The type II secretion machinery allows most Gram-negative bacteria to deliver virulence factors into their surroundings. We report that in Erwinia chrysanthemi, GspE (the putative NTPase), GspF, GspL and GspM constitute a complex in the inner membrane that is presumably used as a platform for assembling other parts of the secretion machinery. The GspE-GspF-GspL-GspM complex was demonstrated by ...

2016
Miao Long Shu-Hua Yang Jian-Xin Han Peng Li Yi Zhang Shuang Dong Xinliang Chen Jiayi Guo Jun Wang Jian-Bin He

Although grape-seed proanthocyanidin extract (GSPE) demonstrates strong anti-oxidant activity, little research has been done to clearly reveal the protective effects on the hepatotoxicity caused by zearalenone (ZEN). This study is to explore the protective effect of GSPE on ZEN-induced oxidative damage of liver in Kunming mice and the possible protective molecular mechanism of GSPE. The results...

2017
Biying Liu Haili Zhang Xiao Tan Daqian Yang Zhanjun Lv Huijie Jiang Jingjing Lu Ruiqi Baiyun Zhigang Zhang

Lead (Pb) is a global environmental health hazard that leads to nephrotoxicity. However, the effective treatment of Pb-induced nephrotoxicity remains elusive. Grape seed procyanidin extract (GSPE) has beneficial properties for multiple biological functions. Therefore, the present study investigated whether GSPE reduced Pb-induced nephrotoxicity as well as the protective mechanism of GSPE in a w...

2015
Esrafil Mansouri Layasadat Khorsandi Maasoumeh Zare Moaiedi

Grape seed proanthocyanidin extract (GSPE) has a broad spectrum of biologic properties against oxidative stress. This study aimed to investigate the effects of GSPE on biochemical factors and antioxidant enzymes of erythrocyte in diabetic rats. Diabetes was induced through single injection of streptozotocin (50 mg.Kg(-1), i.p). Forty Male Sprague-Dawley rats were divided into four Groups: Group...

2017
Àngela Casanova-Martí Joan Serrano M Teresa Blay Ximena Terra Anna Ardévol Montserrat Pinent

Background: Enteroendocrine cells respond to food components by secreting an array of hormones that regulate several functions. We have previously shown that grape seed proanthocyanidins (GSPE) modulate GLP-1 levels. Objective: To deepen on the knowledge of the mechanisms used by GSPE to increase GLP-1, and extend it to its role at modulation of other enterohormones. Design: We used an ex vivo ...

2011
Zhiyan Jia Zhen Song Yuhui Zhao Xiurong Wang Ping Liu

PURPOSE Oxidative damage induced by H₂O₂ treatment can irreversibly damage the lens epithelium, resulting in cell death and cataract. Grape seed extract (GSE) is a widely consumed dietary supplement that has the capability to scavenge oxidants and free radicals. GSE contain 70%-95% standardized proanthocyanidins. The study described herein investigated the protective effect of Grape seed proant...

2017
Masaru GUNJIMA Iwan TOFANI Yukimi KOJIMA Kenshi MAKI Mitsutaka KIMURA

as chelesterol lowering effects, antioxidant effeets, anti-tumor effects, cardioprotective effects, and protection against ultraviolet rays. However, reports of the effects of GSPE on bone are rare. We performed a mechanical analysis ef the effect of GSPE on the interior structure of rat mandibular bone in the growth period, using three-dimensional peripheral quantitative computed tomography (p...

Journal: :Toxicology 2000
D Bagchi M Bagchi S J Stohs D K Das S D Ray C A Kuszynski S S Joshi H G Pruess

Free radicals have been implicated in over a hundred disease conditions in humans, including arthritis, hemorrhagic shock, atherosclerosis, advancing age, ischemia and reperfusion injury of many organs, Alzheimer and Parkinson's disease, gastrointestinal dysfunctions, tumor promotion and carcinogenesis, and AIDS. Antioxidants are potent scavengers of free radicals and serve as inhibitors of neo...

2018
Xingting Liu Xin Lin Yuling Mi Jian Li Caiqiao Zhang

Oxidative stress is an important inducement in ovarian aging which results in fecundity decline in human and diverse animals. As a potent antioxidant, grape seed proanthocyanidin extract (GSPE) was investigated to ameliorate chicken ovarian aging in this study. Firstly, ovarian antioxidant capacity of hens at different ages (90, 150, 280, and 580 days old) was compared to elucidate its age-rela...

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