The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

Antifungal activity of naftifinc (SN 105-843 gel) a napthyle alkyleamine derivative, was measured in vitro against freshly isolated cultures of dermatophytie fungi. Using appropriate concentrations of naftifine, its antifungal activity was compared with the same concentrations of griseofulvin against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton violaceum, Trichophyton tonsuran...

Since certain antitumor drugs also arrest mitosis in metaphase, an attempt was made to determine the effect of oral griseofulvin on methylcholanthrene-induced cutaneous tumors in mice. Contrary to expectations, mice on large doses (1000-1500 mg/kg) of griseofulvin subjected to methylcholanthrene applications had a shorter tumor lag period and developed more and larger tumors than did mice not r...

griseofulvin is a well-known, effective, systemic antifungal agent which has not been used topically in the current clinical practice. in order to treat the common superficial fungal infection of tinea versicolor, a new topical formulation of griseofulvin (1%) was tried in 105 patients during a double blind study and its efficacy compared with placebo (its vehicle) and clotrimazol (1%) solution...

Microtubules have been an attractive target of cancer drug discovery due to their highly dynamic nature during mitosis. Griseofulvin, a natural antifungal compound, is known interfere with microtubule dynamics. In the present study, we prepared and analyzed twenty-seven novel griseofulvin derivatives. Three these compounds had GI50 values <10 ?M (5.74 9.7 ?M) in breast cell line CAL-51. The mos...

El-Nakeeb, Moustafa A. (Rutgers, The State University, New Brunswick, N.J.), and J. O. Lampen. Uptake of griseofulvin by the sensitive dermatophyte, Microsporum gypseum. J. Bacteriol. 89:564-569. 1965.-Actively growing cultures of Microsporum gypseum took up large amounts of griseofulvin-(4-methoxy-H(3)) from the medium. Initially, most of the material could be extracted with hot water, but the...

Griseofulvin 1 is an important antifungal agent that has recently received attention due to its antiproliferative activity in mammalian cancer cells. Study of SAR of some griseofulvin analogues has led to the identification of 2'-benzyloxy griseofulvin 3, a more potent analogue which retards tumor growth through inhibition of centrosomal clustering. However, similar to griseofulvin 1, compound ...

We have previously reported the effects of some antibiotics on experimental rabbit syphilis (Fujita, Asada, and Amawashi, 1962). The recent resurgence of infectious syphilis has led us to look for more effective anti-luetic agents. From this point of view we are studying the ultrastructure of spirochaetes (Hasegawa, Sasahira, and Matsuura, 1965; Hasegawa and Sasahira, 1965; Hasegawa, Komura, an...

Short-term effects of cholic acid ingestion on hepatic accumulation, fecal excretion, and blood levels of protoporphyrin were studied in vivo in griseofulvin-induced protoporphyric mice. Experimental mice that received feed with 2% griseofulvin and 0.5% cholic acid were compared with control mice that received feed with 2% griseofulvin for 4 wk. Five mice from each group were assessed each week...