Background: Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system. The present study investigates the efficacy of Alcoholic extract of grape seeds, an active component of turmeric, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. Materials and Methods: A total of 32 male mice were d...

The skins and seeds of grapes are known to be rich sources of phenolic compounds, both flavonoids and non-flavonoids. The aim of the present study is to determine polyphenolic composition, antioxidant potential along with free radical scavenging activity and antimicrobial properties of ethanol extract of Grape skin and seed. Grape seed showed high antioxidant and antimicrobial activity compared...

Proanthocyanidins (PAs), also called condensed tannins, can protect plants against herbivores and are important quality components of many fruits. Two enzymes, leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR), can produce the flavan-3-ol monomers required for formation of PA polymers. We isolated and functionally characterized genes encoding both enzymes from grapevine (Viti...

Among 60 vining species growing almost exclusively in the Northern hemisphere, only the grapevine (Vitis vinifera L.) (Vitaceae) is the single species largely used in the global wine industry. Grapes are important sources of antioxidants, such as phenolic compounds. The antioxidant activity of these polyphenols is considered much higher than that of the essential vitamins, thus contributing sig...

Background and Objectives: Food wastes are sometimes valuable; of which, seeds are significantly important. Grape seeds, as byproduct of grape processing, contain valuable substances for the production of advanced oils as well as feeds. Therefore, the major aim of this study was to assess moisture sorption isotherms of black grape seeds at various conditions. Materials and Methods: Moisture so...

Grape seed contains many polyphenolic compounds that have potential health-promoting benefits. Among these compounds are proanthocyanidins, also known as condensed tannins, which is a class of flavanols. The basic structural building blocks of flavanols are polyhydroxyflavan-3-ol units linked together by C-C bonds. They are widely distributed in plants but grape seed has very high contents. Thi...

Objective: This study was done on 40 male wistar rats to evaluate the curative and protective effect of grape seeds extract on oxidative damage, inflammatory and apoptotic insult on lung tissue induced by cadmium chloride toxicity. Materials and Methods: The rats were classified to control group (group I), cadmium chloride group (group II), grape seeds extract group (group III) and mixture of g...

Proanthocyanidins, extracted from grape seeds, are widely used mainly as nutritional supplements. However, there has not been a systematic report to investigate toxicological studies on proanthocyanidins, especially in oral administration. In our studies, proanthocyanidin-rich extract from grape seeds was subjected to a series of toxicological tests to document its safety for use in various foo...

Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...