Oral granulomatous diseases are frequently observed due to a wide variety of infections. These represent a unique form of the chronic inflammatory response. Granulomatous diseases of the oral tissues are uncommon and are difficult to diagnose due to various etiological agents. Over the years, emergence of accurate molecular diagnostic techniques has enabled identification of causative organisms...

Histopathological and immunological investigations have been performed in 16 cases of post-traumatic granulomatous (10) and non-granulomatous uveitis (6). Most cases of sympathetic ophthalmitis showed evidence of cell mediated immunity to uveoretinal antigens, though it was not possible to make a definitive diagnosis on immunological grounds alone. Three patients with post-traumatic non-granulo...

The clinical significance of sarcoid-like granulomata in recurrent Crohn's disease has been investigated in 90 patients. The recurrence rate for non-granulomatous disease was double that of granulomatous disease. In granulomatous disease, involvement of the mesenteric lymph nodes did not affect the recurrence rate. This suggests that sarcoid-like granulomata reflect the patients' immune respons...

Granulomatous sebaceous adenitis is characterized by a chronic idiopathic dyskeratosis, with low prevalence in the canine population. This disease results from degeneration and atrophy of glands, so far, no known causes have been attributed. Still, studies suspect genetic involvement, autoimmune response, or anatomical anomalies gland. Sebaceous most often affects dog breeds such as Akita, Samo...

Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatmen...

BACKGROUND The hallmark of tuberculosis is the granuloma, an organized cellular accumulation playing a key role in host defense against Mycobacterium tuberculosis. These structures sequester and contain mycobacterial cells preventing active disease, while long term maintenance of granulomas leads to latent disease. Clear understanding on mechanisms involved in granuloma formation and maintenanc...

Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400ing/kg oxamniquine, p. o.) in the chronic phase o f the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous response. Histopathologic examination o f the animals ’ liver, at 60 days after reinfection, evidenced the presence o f typical granulomas o f the...

26 Abstract Background: The hallmark of tuberculosis is the granuloma, an organized cellular accumulation playing a key role in host defense against Mycobacterium tuberculosis. These structures sequester and contain mycobacterial cells preventing active disease, while long term maintenance of granulomas leads to latent disease. Clear understanding on mechanisms involved in granuloma formation a...

Granulomatous cheilitis is a chronic granulomatous inflammatory condition involving the lips with a multifactorial etiology. The difficulty in treatment of granulomatous cheilitis is reflected in various treatments that have been tried and the lack of consensus regarding the preferred treatment. Combined therapy of intralesional corticosteroid and clofazimine or dapsone is one of the most commo...

Granulomatous infections are commonly associated with mycobacteria, brucellosis, actinomycosis, nocardiosis, spirochetes, and fungi. Rarely, granuloma formation is a host response to other bacterial infection. Osteomyelitis and osteitis that reactivate many years after the primary episode is a known phenomenon. A reactivation that presents as a granulomatous disease is rare. We present a case o...