In this paper, wire electrical discharge machining of D3 tool steel is studied. Influence of pulse-on time, pulse-off time, peak current and wire speed are investigated for MRR, dimensional deviation, gap current and machining time, during intricate machining of D3 tool steel. Taguchi method is used for single characteristics optimization and to optimize all four process parameters simultaneous...

Recently, grey relational analysis (GRA) has been widely applied in analyzing multivariate time series data (MTS); as a solution to the traditional statistical limitations. GRA, which has been proven to be simple and accurate method for analysing relationship in MTS are broadly used in various disciplines such as economics, sociology and engineering. GRA is employed to search for grey relationa...

Background and objectives: Coumarins have potential anticancer effects. Ferulago macrocarpa (Fenzl) Boiss, is a perennial herb which has shown to have several dihydropyranocoumarins like grandivittin (GRA) and dihydrofuranocoumarins such as prantschimgin (PRA). Previously the antibacterial, cytotoxic and antioxidant effect of GRA and PRA have been reported. Understandi...

We propose the following principle to study pointed Hopf algebras, or more generally, Hopf algebras whose coradical is a Hopf subalgebra. Given such a Hopf algebra A, consider its coradical filtration and the associated graded coalgebra grA. Then grA is a graded Hopf algebra, since the coradical A0 of A is a Hopf subalgebra. In addition, there is a projection π : grA → A0; let R be the algebra ...

Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of most of these proteins still remains unknown. We targeted gene knockouts at ten GRA gene loci (GRA1-10) to investigate the cellular roles and esse...

Evaluating and enhancing resilience in water infrastructure is a crucial step towards more sustainable urban water management. As a prerequisite to enhancing resilience, a detailed understanding is required of the inherent resilience of the underlying system. Differing from traditional risk analysis, here we propose a global resilience analysis (GRA) approach that shifts the objective from anal...

Multiple attribute decision making is an important part of modern decision science. It has been extensively applied to various problems. There are several methods for this decision making problem. Based on TOPSIS method and Gray relational analysis method, this paper presents a combined approach to the multi­attribute group decision making. Finally, an...

We earlier showed that 18β-glycyrrhetinic acid (GRA), a pentacyclic triterpenoid from licorice root, could completely cure visceral leishmaniasis in BALB/c mouse model. This was associated with induction of nitric oxide and proinflammatory cytokine production through the up regulation of NF-κB. In the present study we tried to decipher the underlying cellular mechanisms of the curative effect o...

Granzyme A (GrA) and B (GrB) together with perforin are the main constituents of cytotoxic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. The cytotoxic proteins are released to deliver a lethal hit during contact between the CTL or NK cell and target cell. With the use of an enzyme-linked immunosorbent assay for antigenic levels, we showed in a recent study that plasm...