نتایج جستجو برای: gpr15
تعداد نتایج: 63 فیلتر نتایج به سال:
OBJECTIVE Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in IBDs. We aimed to analyse the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via α4β7 and G protein receptor GPR15. DESIGN We assessed the expression of homing receptors on T cells in peripheral blood and inflamed mucosa. We studied the migration pa...
Abstract Environmental factors play a prominent role in the onset of immunological disorders such as ulcerative colitis, but mechanisms are unclear. Diet is major environmental factor, mostly known to influence gut microbiota, which turn affects host immune system. Here, we demonstrated microbiota-independent effect ubiquitous dietary component, L-tryptophan (L-Trp) on mucosal responses. We dis...
Two HIV-1 isolates (CM4 and CM9) able to use alternate HIV-1 coreceptors on transfected cell lines were tested for their sensitivity to inhibitors of HIV-1 entry on primary cells. CM4 was able to use CCR5 and Bob/GPR15 efficiently in transfected cells. The R5 isolate grew in Delta32/Delta32 CCR5 PBMC in the absence or presence of AMD3100, a CXCR4-specific inhibitor, indicating that it uses a re...
It has been established that many simian immunodeficiency virus (SIV) isolates utilize the orphan receptors GPR15 and STRL33 about as efficiently as the chemokine receptor CCR5 for entry into target cells. Most studies were performed, however, with coreceptors of human origin. We found that SIV from captive rhesus macaques (SIVmac) can utilize both human and simian CCR5 and GPR15 with comparabl...
The impact of cigarette smoking can persist for extended periods following smoking cessation and may involve epigenetic reprogramming. Changes in DNA methylation associated with smoking may help to identify molecular pathways that contribute to the latency between exposure and disease onset. Cross-sectional cohort data from subjects in the International COPD Genetics Network (n = 1085) and the ...
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