Thymus-expressed chemokine (TECK) has been reported to chemoattract dendritic cells, thymocytes, and activated macrophages. Here, we show that TECK is a specific agonist for a human orphan receptor called GPR-9-6. We have determined the cDNA sequence of human GPR-9-6 and cloned the corresponding murine cDNA. Human and murine GPR-9-6 expression is very high in the thymus and low in lymph nodes a...

Neuronal circuits commonly receive simultaneous inputs from descending, ascending, and hormonal systems. Thus far, however, most such inputs have been studied individually to determine their influence on a given circuit. Here, we examine the integrated action of the hormone crustacean cardioactive peptide (CCAP) and the gastropyloric receptor (GPR) proprioceptor neuron on the biphasic gastric m...

Gaussian Process Regression (GPR) is a powerful Bayesian method. However, the performance of GPR can be significantly degraded when the training data are contaminated by outliers, including target outliers and input outliers. Although there are some variants of GPR (e.g., GPR with Student-t likelihood (GPRT)) aiming to handle outliers, most of the variants focus on handling the target outliers ...

BACKGROUND Spindle positioning during an asymmetric cell division is of fundamental importance to ensure correct size of daughter cells and segregation of determinants. In the C. elegans embryo, the first spindle is asymmetrically positioned, and this asymmetry is controlled redundantly by two heterotrimeric Galpha subunits, GOA-1 and GPA-16. The Galpha subunits act downstream of the PAR polari...

During the last decade Ground Penetrating Radar (GPR) has proved its ability to act as a powerful geophysical tool for subsurface investigations. GPR is a more user friendly and cost-effective tool due to recent technological developments. Lower cost and simple operation has increased the practice of GPR in the utility locating market as well as other traditional markets. Deploying GPR methods ...

In adults, glucose infusion results in a decreased glucose production rate (GPR) as a mechanism for maintaining euglycemia. To document the development of glucose homeostasis, we derived the GPR in 23 preterm appropriate for gestational age infants, 14 term appropriate for gestational age infants, and in 6 adults. After a 3-h fast, the average plasma glucose and insulin concentration was measur...

In natural speech, for a given speaker, vocal tract length (VTL) is effectively fixed whereas glottal pulse rate (GPR) is varied to indicate prosodic distinctions. This suggests that VTL will be a more reliable cue for identifying a speaker than GPR. It also suggests that listeners will accept larger changes in GPR before perceiving speaker change. We measured the effect of GPR and VTL on the p...

A new recombination operator, called Gene Pool Recombination (GPR) is introduced. In GPR, the genes are randomly picked from the gene pool defined by the selected parents. The mathematical analysis of GPR is easier than for two-parent recombination (TPR) normally used in genetic algorithms. There are n difference equations for the marginal gene frequencies that describe the evolution of a popul...

A 30 m by 30 m two-dimensional grid was designed on a flat bench behind a quarry face of predominantly limestone with thin shale layers located at a Bonner Springs, Kansas site to test the utility of ground-penetrating radar (GPR) for stratigraphic studies. GPR data were collected along seven lines parallel to the quarry face and seven lines perpendicular to the quarry face, each separated by 5...

AIM To investigate the value of the gamma-glutamyltraspeptidase (GGT)-to-platelet (PLT) ratio (GPR) in the diagnosis of hepatic fibrosis in patients with chronic hepatitis B (CHB). METHODS We included 390 untreated CHB patients in this study. The GPR, aspartate aminotransferase (AST)-to-PLT ratio index (APRI), and fibrosis-4 (FIB-4) of all patients were analysed to determine if these paramete...