OBJECTIVE There are limited data on the effects of financial distress (FD) on overall suffering and quality of life (QOL) of patients with advanced cancer (AdCa). In this cross-sectional study, we examined the frequency of FD and its correlates in AdCa. PATIENTS AND METHODS We interviewed 149 patients, 77 at a comprehensive cancer center (CCC) and 72 at a general public hospital (GPH). AdCa c...

When applied to time series processes containing occasional level shifts, the logperiodogram (GPH) estimator often erroneously finds long memory. For a stationary short-memory process with a slowly varying level, I show that the GPH estimator is substantially biased, and I derive an approximation to this bias. The asymptotic bias lies on the (0,1) interval, and its exact value depends on the ra...

In previous work we defined a Quillen model structure, determined by cycles, on the category Gph of directed graphs. In this paper we give a complete description of the homotopy category of graphs associated to our model structure. We endow the categories of N-sets and Z-sets with related model structures, and show that their homotopy categories are Quillen equivalent to the homotopy category H...

The specificity of the vertebrate hypothalamic-pituitary-gonadal and hypothalamic-pituitary-thyroid axes is explained by the evolutionary refinement of the specificity of expression and selectivity of interaction between the glycoprotein hormones GpH (FSH, LH, and TSH) and their cognate receptors GpH-R (FSH-R, LH-R, and TSH-R). These two finely tuned signaling pathways evolved by gene duplicati...

The approximately 200,000-mile fuel pipeline system in the U.S. operates at flow rates up to 2.5 x 10 gallons per hour (GPH). Most commercial technologies only provide on-line leak detection at about 0.3% of flow rate, i.e., about 7,500 GPH or larger. Detection of leaks at about 1 GPH or so is desirable both from a regulatory and leak-prevention standpoint. Brookhaven’s commercially-accepted pe...

Secretion of the pituitary glycoprotein hormones (GpH) follitropin, lutropin, and thyrotropin in vertebrates is the main mechanism by which neuroendocrine signals are propagated at the level of the peripheral glands, gonads and thyroid. Receptors of these hormones (glycoprotein hormone receptors, GpH-R) evolved from a common ancestor through gene duplication and subsequent functional divergence...

A full-length transcript encoding a functional lamprey glycoprotein hormone receptor I (lGpH-R I, GenBank AY750688) was cloned from the testes of the sea lamprey, Petromyzon marinus, using the GpH-R protein fingerprint GLYCHORMONER from the PRINTS database. The present study is the first to identify a GpH-R transcript in an agnathan, which is one of the only two representatives of the oldest li...

There are species differences between human histamine H(1) receptor (hH(1)R) and guinea pig (gp) histamine H(1) receptor (gpH(1)R) for phenylhistamines and histaprodifens. Several studies showed participation of the second extracellular loop (E2-loop) in ligand binding for some G protein-coupled receptors (GPCRs). Because there are large species differences in the amino acid sequence between hH...