In the United States, almost 120,000 females under the age of 50 years are diagnosed with cancer annually [ 1 ] . Retaining reproductive potential is extremely important to those diagnosed with cancer, and reproductive compromise can cause distress well into survivorship [ 2, 3 ] . Despite this, patients often do not recall discussions at diagnosis regarding fertility and options for fertility ...

Recent epidemiological studies estimate that approximately 1 in every 1,300 young males in the United States is a childhood cancer survivor [ 1 ] . Of this population, approximately 30% received gonadotoxic cancer treatments that resulted in permanent infertility [ 2 ] . Therefore, approximately 1 in every 5,000 young males is at risk for infertility due to their pediatric cancer treatment. Thi...

OBJECTIVE The aim of the study reported here was to investigate the protective effect of gonadotropin-releasing hormone analog (GnRHa) against cyclophosphamide (CTX)-induced gonadotoxicity. METHODS Eighty Fischer 344 rats were divided randomly into four groups (20 per group). One group received normal saline, one GnRHa, one CTX, and one GnRHa+CTX. Several parameters were used to observe the o...

Hematopoietic stem cell transplantation (HSCT) is associated with significant posttransplantation gonadotoxicity. This deficit has been mainly attributed to pretransplantation conditioning, but lower sperm counts in humans also appear to be associated with graft-versus-host disease (GVHD) following allogeneic HSCT. However, the mechanisms leading to diminished spermatocyte levels during GVHD re...

Epithelial ovarian cancer (EOC) continues to represent one of the most lethal conditions in women in the western countries. With the shifting of childbearing towards higher age, EOC increasingly affects women with active childbearing wish, resulting in major impacts on treatment management. Next to the optimal therapeutic treatment strategies, gynecologic oncologists are being asked to incorpor...