The importance of diversification and risk management was recognized by a few visionaries in the early days of investing. Only in the 1950's, however, did these concepts become central. Since then, increasingly sophisticated mathematical and statistical tools have been brought to bear on the problem of estimating the aggregate risk of a portfolio. This risk depends crucially on the covariances ...

abstract goldberg-shprintzen syndrome (omim 609460) (goshs) is an autosomal recessive multiple congenital anomaly syndrome distinguished by intellectual disability, microcephaly, and dysmorphic facial characteristics. most affected individuals also have hirschsprung disease and/or gyral abnormalities of the brain. this syndrome has been shown to be associated with kiaa1279 gene mutations at 10q...

Adrienne S. Glaich, MD; Leonard H. Goldberg, MD, FRCP; Tianhong Dai, PhD; Joy H. Kunishige, MD; Paul M. Friedman, MD; DermSurgery Associates, Houston, Texas (Drs Glaich, Goldberg, and Friedman); and Departments of Dermatology, Weill Cornell Medical College, Methodist Hospital, Houston (Drs Goldberg and Friedman), Harvard Medical School, Boston, Massachusetts (Dr Dai), and The University of Texa...

As a security researcher, my goal is to develop practical solutions that make computer networks more reliable, predictable, and resilient to attack. To address the grand challenges in security research, I believe that we need to go beyond traditional disciplinary barriers. For instance, cryptography is crucial to deal with hacked devices and malicious parties, but cannot deal with the fact that...