Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Hand2 (GHMT) directly reprogram fibroblasts into cardiomyocyte-like cells (iCMs). However, the critical timing of transgene expression and the molecular mechanisms for cardiac reprogramming remain unclear. The conventional doxycyclin...

Social media data are amenable to representation by directed graphs. A node represents an entity in the social network such as a person, organization, location, or event. A link between two nodes represents a relationship such as communication, participation, or financial support. When stored in a database, these graphs can be searched and analyzed for occurrences of various subgraph patterns o...

We evaluated three nonreplicating dengue virus type 2 (DENV-2) vaccines: (i) a DNA vaccine containing the prM-E gene region (D), (ii) a recombinant subunit protein vaccine containing the B domain (i.e., domain III) of the E protein as a fusion with the Escherichia coli maltose-binding protein (R), and (iii) a purified inactivated virus vaccine (P). Groups of four rhesus macaques each were prime...

Gelatinous bone marrow transformation (GMT) is a rare disorder of unknown pathogenesis. It is characterized by fat cell atrophy, focal loss of hematopoietic cells and deposition of extracellular gelatinous substances, which histochemically are mucopolysaccharides and rich in hyaluronic acid. GMT occurs more often in adults males than in females. The spectrum of underlying diseases is heterogene...

Submitted on:09-Oct-2013, 03:30:04 AM GMT Accepted on:09-Nov-2013, 01:34:11 AM GMT Published on:15-Nov-2013, 05:37:14 AM GMT Article ID: WMCPLS0074 Article Type: Original Articles Article URL: http://webmedcentralplus.com/article_view/74 Subject Categories:OBSTETRICS AND GYNAECOLOGY

RATIONALE After myocardial infarction (MI), massive cell death in the myocardium initiates fibrosis and scar formation, leading to heart failure. We recently found that a combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), reprograms fibroblasts directly into functional cardiomyocytes in vitro. OBJECTIVE To investigate whether viral gene transfer of GMT into infarcte...

Guanmaitong (GMT) is a traditional Chinese herbal compound that has been used for the treatment of coronary heart disease (CHD) and other cardiovascular diseases. However, the efficacy of GMT in treating cardiovascular diseases remains unclear. The aim of the present study was to investigate the protective mechanisms and identify the targeted proteins and signaling networks associated with the ...

A time zone is an area on the Earth globe that observes a uniform or standard in its area, better known as local time. The zones worldwide differ according to longitude of country and ASEAN countries have four zones, namely, GMT+6.5, GMT+7, GMT+8 GMT+9. Time result different environments aspects socio-ibadah (religious worship), working hours timings for other purposes. Indeed, there been many ...

INTRODUCTION HIV pre-exposure prophylaxis (PrEP) has emerged as a key component of contemporary HIV combination prevention strategies. To explore the local suitability of PrEP, country-specific acceptability studies are needed to inform potential PrEP implementation. In the context of Myanmar, in addition to resource constraints, HIV service access by gay men, other men who have sex with men, a...

The Saccharomyces cerevisiae GDP-mannose transporter (GMT) encoded by the essential gene VRG4/VIG4 is a member of the nucleotide-sugar transporter family in the Golgi apparatus. We examined GMT in the secretory mutant cells to investigate the mechanism of its localization in the Golgi. At the nonpermissive temperature, most GMT was found in the endoplasmic reticulum of sec23ts cells, which have...