Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry. This species contains a myriad of phytochemicals including the major saponin glycoside glycyrrhizin (G) of Glycyrrhetinic acid (GA) aglycone. In this study, 2D-ROESY NMR technique was successfully applied for distinguishi...

Extracts from Glycyrrhiza are traditionally used for the treatment of insomnia and anxiety. Glabridin is one of the main flavonoid compounds from Glycyrrhiza glabra and displays a broad range of biological properties. In the present work, we investigated the effect of glabridin on GABAA receptors. For this purpose, we employed the two-electrode voltage-clamp technique on Xenopus laevis oocytes ...

The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as hops (Humulus lupulus) and licorice (Glycyrrhiza spec.) to manage menopausal symptoms. Previous studies have shown estrogenic properties for hops, likely due to the presence of 8-prenylnarigenin, and chemopreventive effects mainly attrib...

1 Department of Pharmaceutical Botany, Faculty of Pharmacy, “V. Babeș” University of Medicine and Pharmacy, Timișoara 2 Department of Biochemistry, “V. Babeș” University of Medicine and Pharmacy, Timișoara 3 Department of Toxicology, Faculty of Pharmacy, “V. Babeș” University of Medicine and Pharmacy, Timișoara 4 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “V. Babeș” University...

Objectives About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients. This study aimed to assess the preventive effect of Glycyrrhiza aqueous extract on oral mucositis in cancer patients under head and neck radiotherapy. Materials and Methods In this d...

The genus Glycyrrhiza consists of about 30 species in which G. glabra, G. uralensis, G. inflata, G. aspera, G. korshinskyi, and G. eurycarpa are generally recognized as licorice because of their sweet taste. Except G. korshinskyi, we examined isoprenoid-substituted phenols of these licorices. Each plant could be characterized by some isoprenoid phenols. We also investigated the biological activ...

This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate in...

In this paper we have analyzed the phytoestrogen content of Glycyrrhiza glabra roots harvested from four different locations in Syria. The presence of eight phytoestrogen compounds was simultaneously assessed through a LC-MS method, before and after hydrolysis. All tested extracts contain daidzein, daidzin, genistein, formononetin, ononin and coumestrol. Rezumat În această lucrare am analizat c...

The aim of the present study was to introduce an alternative way for insects control through biodegradable plants materials. The different cold water extracts dilutions of Acacia modesta and Glycyrrhiza glabra were tested against Tribolium castaneum. The extracts dilutions of both plants caused mortality of the Tribolium castaneum. ANOVA revealed that dilutions and plants were highly significan...

There is an increasing demand for herbal medicines, health products, pharmaceuticals. Glycyrrhiza glabra Linn is a plant used in traditional medicine across the world for its ethnopharmacological value. It is found to contain important phytoconstituents such as glycyrrhizin, glycyrrhizinic acid, glabrin A and B and isoflavones. It is effectively used as anti-inflammatory, anti-bacterial, anti-f...