1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted under mild O'Donnell conditions into the corresponding L-histidine derivative. After deprotection L...

The relatlon between the bonding eMcacy ef the dentin adhesive and the physical change of the dentin after treatment with various dentin cleansers was investigated, The dentin surface was cleaned with one of the seven experimental dentin cleansers, 5, 10, 20, 30 and 40% of the phosphoric acid, neutralized O,5M EDTA solution (pH7.4) and 9.1% pyruvic acid containing 9,1% glycin, prior to the comb...

BACKGROUND AND AIMS Although delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia, the efficacy of prokinetic drugs has not been established. Recent studies using macrolide prokinetics were negative but receptor desensitisation may have played a role. The aim of the present study was to evaluate the influence on meal induced symptoms of acutely adm...

Background and aims: Although delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia, the efficacy of prokinetic drugs has not been established. Recent studies using macrolide prokinetics were negative but receptor desensitisation may have played a role. The aim of the present study was to evaluate the influence on meal induced symptoms of acutely ad...