OBJECTIVE Glycated hemoglobin was recently recommended for use as a diagnostic test for diabetes. We examined the association between 2010 American Diabetes Association diagnostic cut points for glycated hemoglobin and microvascular outcomes (chronic kidney disease, end-stage renal disease [ESRD], and retinopathy) and formally tested for the presence of risk thresholds in the relationships of g...

OBJECTIVE Glycated hemoglobin has been suggested to be superior to fasting glucose for the prediction of vascular disease and death from any cause. The aim of the present work was to analyze and compare the predictive value of glycated hemoglobin and fasting glucose on all-cause and cause-specific mortality in subjects who underwent coronary angiography. RESEARCH DESIGN AND METHODS We studied...

objective: type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. vitamin e supplementation reduces oxidative stress level in diabetic pa-tients. purpose of this study was to evaluate the effect of vitamin e supplementation on glycemic control and lipid profile in type 2 diabetic patients. material and methods: in this study 31 type 2 diabetic patients ...

We estimated glycated ("glycosylated") hemoglobin in erythrocytes of hemodialyzed uremic patients by the aminophenylboronic acid affinity-chromatographic method and by an ion-exchange chromatographic method. As expected, apparent HbA1 concentrations were above normal in the uremic patients, owing to interference by the carbamylated hemoglobin. However, there was no significant difference betwee...

We have devised a rapid and convenient method of eliminating the contribution of labile glycosylated hemoglobin in the hemoglobin A1 assay. The procedure requires a 30-min incubation of erythrocytes in 30 mM semicarbazide and 12 mM aniline (pH 5, 38 degrees C). This chemical means of eliminating the labile fraction is as effective as a 14-h incubation in isotonic saline as measured with high-pr...

We studied the influence of many variables on the cation-exchange chromatographic determination of glycohemoglobin was minicolumns (HbA1) and with macrocolumns (HbA1a+b and HbA1c). Minicolumns are most sensitive to buffer composition. The best conditions are pH 6.78 and sodium, potassium, and phosphate concentrations of 54.8, and 36 mmol/L, respectively. In fact, there is no clear cut-off point...

Type 2 diabetes is a leading cause of morbidity and mortality. While genetic variants have been found to influence the risk of type 2 diabetes mellitus, relatively few studies have focused on genes associated with glycated hemoglobin, an index of the mean blood glucose concentration of the preceding 8-12 weeks. Epidemiologic studies and randomized clinical trials have documented the relationshi...

INTRODUCTION o o o o o o o o o o o o o o 0 . 0 o o o o o o o o o O O O 0 .0 o o 0 -0 0 O O O O O O O O 0 . 0 O O O O O O o o Statement of the Problem , Purpose of the Study . = , Significance of the Study Conceptual Framework . „ , Definition of Terms » „ , REVIEW OF THE LITERATURE o O 0 , 0 O O O O O O O o Compliance with a Medical Regimen . . . Diabetes Mellitus and Glycohemoglobin Glycohemog...