Some studies suggested that glucocorticoid receptors activities can modulate fear and anxiety. According to that, the purpose of this research is to assess the modulatory effect of glucocorticoid receptors on the anxiety assessed in plus maze. In this research mice with medium weight of 20-25 g were used. The male and female animals separately sorted in two groups as control and experiment rand...

we present a 21-years old woman with alopecia universalis, generalized vitiligo, and graves' disease. she had had thyroidectomy in early childhood and was receiving replacement therapy with levothyroxine. the patient was treated with systemic puva and glucocorticoid in combination with topical treatment for alopecia. after 6 months of treatment, alopecia was reversed but vitiligo was unchanged.

Polymyalgia rheumatica was officially recognised as a distinct clinical entity six decades ago, acknowledged in an editorial published The Lancet March, 1961. 1 LancetPolymyalgia rheumatica. Lancet. 1961; 1: 597-599 Google Scholar At that time, the effectiveness of glucocorticoids treatment disease already noted, initially at doses 30–40 mg prednisone per day and later currently recommended sta...

background: long-term glucocorticoid therapy causes secondary osteoporosis leading to pathological fractures. glucocorticoid action in bone is dependant upon the activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme (11β-hsd1). piper sarmentosum is a local herb that possesses the ability to inhibit 11-βhsd1 enzyme activity. we aimed to determine the effects of piper sarmentosum water extra...

one of the main components of the stress system is hypothalamus- pituitary-adrenal (hpa) axis. acute activation of µ-opioid receptors increases the activity of the hpa axis, leading to release of acth and corticosterone. glucocorticoids can change behaviors, depend on age but there were no evidences about the interaction between age, opioid system and glucocorticoids. in this experiment, effect...

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Abstract Background Glucocorticoid-induced hyperglycemia is a problem-facing endocrinologists and internal medicine specialists in hospital wards. Case History A 63-year-old woman with type 2 diabetes was admitted to the acute exacerbation of chronic obstructive airway disease. She treated short course intravenous hydrocortisone followed by oral prednisolone. On discharge, she attended her regu...

Glucocorticoids play an important role in the treatment of a number of hematological malignancies, such as multiple myeloma. The effects of glucocorticoids are mediated through the glucocorticoid receptor alpha, the abundance of which can be modulated by alternative splicing of the glucocorticoid receptor mRNA. Two splice variants of the glucocorticoid receptor mRNA have been described: glucoco...

We have examined the influence of intracellular vitamin B6 concentration on glucocorticoid receptor function in HeLa S3 cells transfected with a glucocorticoid-responsive chloramphenicol acetyltransferase (CAT) reporter plasmid. CAT activity is induced from this plasmid specifically by glucocorticoid hormones in a glucocorticoid receptor-dependent manner. The intracellular concentration of pyri...

Title of Document: ROLE OF EPIGENETIC MODIFICATIONS AND DEXRAS1 IN GLUCOCORTICOID REGULATION OF GROWTH HORMONE EXPRESSION Jyoti Narayana Doctor of Philosophy, 2011 Directed By: Professor Tom E. Porter, PhD Department of Animal and Avian Sciences Biological Sciences Graduate Program Glucocorticoid induction of growth hormone in anterior pituitary cells of embryonic chickens is an indirect effect...