Background & Aim: Cutaneous infection caused by protozoa the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries including Middle East, Africa and Latin America. In the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. Experimental: In this study, the in vivo effica...

A 20 years old patient from Pakistan admitted to the hospital with fever chills cough sputum discharge and skin sore on the right wrist. In physical examination: Anemia, butterfuly pigmentation on his face, scaltered rounded pigmentation on the lower limbs enlarged spleen reaching left. iliac fossa enlarged firm liver, moist and dry rales at the base of the lungs was found on physical examinati...

Since the bone marrow puncture and its study is a time-consuming and costly process and in addition, the direct agglutination test has a high sensitivity and is easier and quicker to perform for the diagnosis of Kala-azar, and considering the less value of bone marrow puncture for the definite diagnosis of endemic hepatosplenomegaly in Meshkinshahr, this study was performed to determine the dia...

Objective(s): Because leishmaniasis is related to the impaired functioning of T-cells, the use of an immunomodulator can increase the efficacy of antileishmanial therapy in visceral leishmaniasis. In this study, we used shark cartilage extract with artemisinin and glucantime against visceral leishmaniasis in BALB/c mice, and evaluated the synergistic therapeutic effect. Materials and Methods: Th...

Few case series provide a current, comprehensive, and detailed description of splenic infarction (SI), an uncommon condition. Retrospective chart review complemented by imaging evaluation and patient follow-up. All adult patients with a confirmed diagnosis of acute SI discharged over 10 years from a single academic center were studied. A systematic literature review was done to compile a comple...